Reliability and Responsiveness of Cardiopulmonary Exercise Testing in Fatigued Persons with Multiple Sclerosis and Low to Mild Disability

M. Heine, L.E. van den Akker, O. Verschuren, A. Visser-Meily, G. Kwakkel

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Background: Peak oxygen uptake (VO2peak) via cardiopulmonary exercise testing is considered the gold standard for testing aerobic capacity in healthy participants and people with various medical conditions. The reliability and responsiveness of cardiopulmonary exercise testing outcomes in persons with MS (PwMS) have not been extensively studied. Objective: (1) to investigate the reliability of cardiopulmonary exercise parameters in PwMS; (2) to determine the responsiveness, in terms of the smallest detectable change (SDC), for each parameter. Design: Two repeated measurements of cardiopulmonary exercise outcomes were obtained, with a median time interval of 16 days. Methods: Thirty-two PwMS suffering from subjective fatigue performed cardiopulmonary exercise tests on a cycle ergometer, to voluntary exhaustion. We calculated the reliability, in terms of the intra-class correlation coefficient (ICC [2,k]; absolute agreement), and the measurement error, in terms of standard error of measurement (SEM) and SDC at individual (SDC
    Original languageEnglish
    Article numbere0122260
    JournalPLoS ONE
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Dive into the research topics of 'Reliability and Responsiveness of Cardiopulmonary Exercise Testing in Fatigued Persons with Multiple Sclerosis and Low to Mild Disability'. Together they form a unique fingerprint.

    Cite this