Renal function in familial longevity: the Leiden Longevity Study

Moniek C M de Goeij, Nynke Halbesma, Friedo W Dekker, Carolien A Wijsman, Diana van Heemst, Andrea B Maier, Simon P Mooijaart, P Eline Slagboom, Rudi G J Westendorp, Anton J M de Craen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included. Information was collected on lifestyle, medical history, medication use, and a non-fasting blood sample was drawn. Renal function (estimated glomerular filtration rate, eGFR) was assessed with the Chronic Kidney Disease epidemiology collaboration (CKD-EPI) formula. Linear mixed models were used to account for familial dependencies within the offspring and all analyses were stratified by sex. eGFR was similar between female offspring and female controls (0.44ml/min/1.73m(2) (SE 0.72) difference, p=0.54, age-adjusted). Male offspring had a higher eGFR compared to male controls (1.78ml/min/1.73m(2) (SE 0.78) difference, p=0.022, age-adjusted), and further adjustments for various characteristics did not materially change this difference. Among men with a history of hypertension, or myocardial infarction and/or stroke, offspring had a higher eGFR compared to controls (4.74ml/min/1.73m(2) (SE 1.53) difference, p=0.002, age-adjusted, and 6.21ml/min/1.73m(2) (SE 2.85) difference, p=0.033, age-adjusted, respectively). Middle-aged men, but not women, with a propensity for longevity have better renal function compared to environmentally matched controls, especially among those with a history of cardiovascular disease.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalExperimental Gerontology
Volume51
DOIs
Publication statusPublished - Mar 2014

Bibliographical note

Copyright © 2013 Elsevier Inc. All rights reserved.

Keywords

  • Aged
  • Cardiovascular Diseases/physiopathology
  • Case-Control Studies
  • Female
  • Glomerular Filtration Rate/physiology
  • Humans
  • Hypertension/physiopathology
  • Kidney/physiology
  • Longevity/genetics
  • Male
  • Middle Aged
  • Sex Characteristics
  • Sex Factors

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