Renal function in familial longevity: the Leiden Longevity Study

Moniek C M de Goeij, Nynke Halbesma, Friedo W Dekker, Carolien A Wijsman, Diana van Heemst, Andrea B Maier, Simon P Mooijaart, P Eline Slagboom, Rudi G J Westendorp, Anton J M de Craen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included. Information was collected on lifestyle, medical history, medication use, and a non-fasting blood sample was drawn. Renal function (estimated glomerular filtration rate, eGFR) was assessed with the Chronic Kidney Disease epidemiology collaboration (CKD-EPI) formula. Linear mixed models were used to account for familial dependencies within the offspring and all analyses were stratified by sex. eGFR was similar between female offspring and female controls (0.44ml/min/1.73m(2) (SE 0.72) difference, p=0.54, age-adjusted). Male offspring had a higher eGFR compared to male controls (1.78ml/min/1.73m(2) (SE 0.78) difference, p=0.022, age-adjusted), and further adjustments for various characteristics did not materially change this difference. Among men with a history of hypertension, or myocardial infarction and/or stroke, offspring had a higher eGFR compared to controls (4.74ml/min/1.73m(2) (SE 1.53) difference, p=0.002, age-adjusted, and 6.21ml/min/1.73m(2) (SE 2.85) difference, p=0.033, age-adjusted, respectively). Middle-aged men, but not women, with a propensity for longevity have better renal function compared to environmentally matched controls, especially among those with a history of cardiovascular disease.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalExperimental Gerontology
Volume51
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Glomerular Filtration Rate
Kidney
Epidemiology
Chronic Renal Insufficiency
Life Style
Siblings
Linear Models
Cardiovascular Diseases
Stroke
Myocardial Infarction
Hypertension
Blood

Bibliographical note

Copyright © 2013 Elsevier Inc. All rights reserved.

Keywords

  • Aged
  • Cardiovascular Diseases/physiopathology
  • Case-Control Studies
  • Female
  • Glomerular Filtration Rate/physiology
  • Humans
  • Hypertension/physiopathology
  • Kidney/physiology
  • Longevity/genetics
  • Male
  • Middle Aged
  • Sex Characteristics
  • Sex Factors

Cite this

de Goeij, M. C. M., Halbesma, N., Dekker, F. W., Wijsman, C. A., van Heemst, D., Maier, A. B., ... de Craen, A. J. M. (2014). Renal function in familial longevity: the Leiden Longevity Study. Experimental Gerontology, 51, 65-70. https://doi.org/10.1016/j.exger.2013.12.012
de Goeij, Moniek C M ; Halbesma, Nynke ; Dekker, Friedo W ; Wijsman, Carolien A ; van Heemst, Diana ; Maier, Andrea B ; Mooijaart, Simon P ; Slagboom, P Eline ; Westendorp, Rudi G J ; de Craen, Anton J M. / Renal function in familial longevity : the Leiden Longevity Study. In: Experimental Gerontology. 2014 ; Vol. 51. pp. 65-70.
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de Goeij, MCM, Halbesma, N, Dekker, FW, Wijsman, CA, van Heemst, D, Maier, AB, Mooijaart, SP, Slagboom, PE, Westendorp, RGJ & de Craen, AJM 2014, 'Renal function in familial longevity: the Leiden Longevity Study' Experimental Gerontology, vol. 51, pp. 65-70. https://doi.org/10.1016/j.exger.2013.12.012

Renal function in familial longevity : the Leiden Longevity Study. / de Goeij, Moniek C M; Halbesma, Nynke; Dekker, Friedo W; Wijsman, Carolien A; van Heemst, Diana; Maier, Andrea B; Mooijaart, Simon P; Slagboom, P Eline; Westendorp, Rudi G J; de Craen, Anton J M.

In: Experimental Gerontology, Vol. 51, 03.2014, p. 65-70.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Renal function in familial longevity

T2 - the Leiden Longevity Study

AU - de Goeij, Moniek C M

AU - Halbesma, Nynke

AU - Dekker, Friedo W

AU - Wijsman, Carolien A

AU - van Heemst, Diana

AU - Maier, Andrea B

AU - Mooijaart, Simon P

AU - Slagboom, P Eline

AU - Westendorp, Rudi G J

AU - de Craen, Anton J M

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2014/3

Y1 - 2014/3

N2 - Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included. Information was collected on lifestyle, medical history, medication use, and a non-fasting blood sample was drawn. Renal function (estimated glomerular filtration rate, eGFR) was assessed with the Chronic Kidney Disease epidemiology collaboration (CKD-EPI) formula. Linear mixed models were used to account for familial dependencies within the offspring and all analyses were stratified by sex. eGFR was similar between female offspring and female controls (0.44ml/min/1.73m(2) (SE 0.72) difference, p=0.54, age-adjusted). Male offspring had a higher eGFR compared to male controls (1.78ml/min/1.73m(2) (SE 0.78) difference, p=0.022, age-adjusted), and further adjustments for various characteristics did not materially change this difference. Among men with a history of hypertension, or myocardial infarction and/or stroke, offspring had a higher eGFR compared to controls (4.74ml/min/1.73m(2) (SE 1.53) difference, p=0.002, age-adjusted, and 6.21ml/min/1.73m(2) (SE 2.85) difference, p=0.033, age-adjusted, respectively). Middle-aged men, but not women, with a propensity for longevity have better renal function compared to environmentally matched controls, especially among those with a history of cardiovascular disease.

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KW - Aged

KW - Cardiovascular Diseases/physiopathology

KW - Case-Control Studies

KW - Female

KW - Glomerular Filtration Rate/physiology

KW - Humans

KW - Hypertension/physiopathology

KW - Kidney/physiology

KW - Longevity/genetics

KW - Male

KW - Middle Aged

KW - Sex Characteristics

KW - Sex Factors

U2 - 10.1016/j.exger.2013.12.012

DO - 10.1016/j.exger.2013.12.012

M3 - Article

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JF - Experimental Gerontology

SN - 0531-5565

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