Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

Rogier J Scherder; M J van Dorp; A J Prins; C van Klaveren; I Cornelisz; J Killestein; Henry C Weinstein

doi:10.7224/1537-2073.2021-030

Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

Rogier J Scherder, M J van Dorp, A J Prins, C van Klaveren, I Cornelisz, J Killestein, Henry C Weinstein

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances.

METHODS: Forty-six patients with MS experiencing pain participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, and relative amplitude. Pain was assessed using visual and verbal analog scales, mood by the Beck Depression Inventory and Symptom Checklist-90, and physical disability by the Expanded Disability Status Scale.

RESULTS: Incorporating mood, pain, and physical disability into 1 regression model resulted in a significant association with interdaily stability.

CONCLUSIONS: Compared with intradaily variability and relative amplitude, interdaily stability seems to be the most vulnerable actigraphy variable for mood disturbances, pain, and physical disabilities.

Original language	English
Pages (from-to)	157-162
Number of pages	6
Journal	International journal of MS care
Volume	25
Issue number	4
DOIs	https://doi.org/10.7224/1537-2073.2021-030
Publication status	Published - 2023

Bibliographical note

Funding

The authors are most grateful to all the study participants and to the team at Nieuw Unicum, Zandvoort, the Netherlands.

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10.7224/1537-2073.2021-030

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title = "Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis",

abstract = "BACKGROUND: Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances.METHODS: Forty-six patients with MS experiencing pain participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, and relative amplitude. Pain was assessed using visual and verbal analog scales, mood by the Beck Depression Inventory and Symptom Checklist-90, and physical disability by the Expanded Disability Status Scale.RESULTS: Incorporating mood, pain, and physical disability into 1 regression model resulted in a significant association with interdaily stability.CONCLUSIONS: Compared with intradaily variability and relative amplitude, interdaily stability seems to be the most vulnerable actigraphy variable for mood disturbances, pain, and physical disabilities.",

author = "Scherder, {Rogier J} and {van Dorp}, {M J} and Prins, {A J} and {van Klaveren}, C and I Cornelisz and J Killestein and Weinstein, {Henry C}",

note = "{\textcopyright} 2023 The Consortium of Multiple Sclerosis Centers.",

year = "2023",

doi = "10.7224/1537-2073.2021-030",

language = "English",

volume = "25",

pages = "157--162",

journal = "International journal of MS care",

issn = "1537-2073",

publisher = "Consortium of Multiple Sclerosis",

number = "4",

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TY - JOUR

T1 - Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

AU - Scherder, Rogier J

AU - van Dorp, M J

AU - Prins, A J

AU - van Klaveren, C

AU - Cornelisz, I

AU - Killestein, J

AU - Weinstein, Henry C

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances.METHODS: Forty-six patients with MS experiencing pain participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, and relative amplitude. Pain was assessed using visual and verbal analog scales, mood by the Beck Depression Inventory and Symptom Checklist-90, and physical disability by the Expanded Disability Status Scale.RESULTS: Incorporating mood, pain, and physical disability into 1 regression model resulted in a significant association with interdaily stability.CONCLUSIONS: Compared with intradaily variability and relative amplitude, interdaily stability seems to be the most vulnerable actigraphy variable for mood disturbances, pain, and physical disabilities.

AB - BACKGROUND: Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances.METHODS: Forty-six patients with MS experiencing pain participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, and relative amplitude. Pain was assessed using visual and verbal analog scales, mood by the Beck Depression Inventory and Symptom Checklist-90, and physical disability by the Expanded Disability Status Scale.RESULTS: Incorporating mood, pain, and physical disability into 1 regression model resulted in a significant association with interdaily stability.CONCLUSIONS: Compared with intradaily variability and relative amplitude, interdaily stability seems to be the most vulnerable actigraphy variable for mood disturbances, pain, and physical disabilities.

U2 - 10.7224/1537-2073.2021-030

DO - 10.7224/1537-2073.2021-030

M3 - Article

C2 - 37469337

SN - 1537-2073

VL - 25

SP - 157

EP - 162

JO - International journal of MS care

JF - International journal of MS care

IS - 4

ER -

Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

Abstract

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