Retinal layer thickness in preclinical Alzheimer's disease

Jacoba A van de Kreeke, Hoang-Ton Nguyen, Jurre den Haan, Elles Konijnenberg, Jori Tomassen, Anouk den Braber, Mara Ten Kate, Lyduine Collij, Maqsood Yaqub, Bart van Berckel, Adriaan A Lammertsma, Dorret I Boomsma, Hendra Stevie Tan, Frank D Verbraak, Pieter Jelle Visser

Research output: Contribution to JournalArticle

Abstract

PURPOSE: There is urgent need for non-invasive diagnostic biomarkers in the preclinical phase of Alzheimer's Disease (AD). Several studies suggest that retinal thickness is reduced in AD. Here, we aim to test the diagnostic value of retinal thickness in preclinical AD, as defined by cognitively normal individuals with amyloid pathology on PET.

METHODS: One hundred and sixty five cognitively healthy monozygotic twins aged ≥ 60 were included from the Netherlands Twin Register taking part in the European Medical Information Framework for Alzheimer's Disease PreclinAD study. Participants underwent [18 F] flutemetamol PET that was visually rated for presence or absence of cortical amyloid beta (Aβ). Binding potential (BPND ) was calculated as continuous measure for Aβ. Spectral Domain OCT was used to asses total and individual inner retinal layer thickness in the macular region (ETDRS circles) as well as peripapillary retinal nerve fibre layer (pRNFL) thickness. Differences between Aβ+ and Aβ- individuals and associations between BPND and retinal thickness were analyzed.

RESULTS: No differences were found in retinal layer thickness in the macula or pRNFL between Aβ+ and Aβ- individuals. A positive associations between BPND and macular total retinal thickness was observed in the inner ring (p = 0.018), but this was not statistically significant after correction for multiple testing (p = 0.144). Brain/eye parameters had moderate to high intra-twin correlations (p < 0.001) except visual rating score of Aβ, which did not correlate (r = 0.21, p = 0.068).

CONCLUSION: Variation in retinal thickness likely reflects genetic differences between individuals, but cannot discriminate between healthy and preclinical AD cases, making its use as biomarker in these early stages limited.

Original languageEnglish
Pages (from-to)798-804
Number of pages7
JournalActa Ophthalmologica
Volume97
Issue number8
DOIs
Publication statusPublished - Dec 2019

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Bibliographical note

© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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van de Kreeke, J. A., Nguyen, H-T., den Haan, J., Konijnenberg, E., Tomassen, J., den Braber, A., ... Visser, P. J. (2019). Retinal layer thickness in preclinical Alzheimer's disease. Acta Ophthalmologica, 97(8), 798-804. https://doi.org/10.1111/aos.14121