Retinoblastoma: MR imaging parameters in detection of tumor extent

P. de Graaf, F. Barkhof, A.C. Moll, S.M. Imhof, D.L. Knol, P. van der Valk, J.A. Castelijns

    Research output: Contribution to JournalArticleAcademicpeer-review


    PURPOSE: To assess diagnostic accuracy of preoperatively performed magnetic resonance (MR) imaging for detection of tumor extent in a large patient population with histopathologically proved retinoblastoma. MATERIALS AND METHODS: Local ethics committee approval and informed consent were not required for retrospective review of patients' images and records. Fifty-eight eyes in 28 girls (mean age, 21 months; range, 2-59 months) and 28 boys (mean age, 24 months; range, 2-76 months) with retinoblastoma were retrospectively reviewed by one radiologist on unenhanced T1-weighted, dual-echo T2-weighted, and gadolinium-enhanced T1-weighted MR images. MR imaging parameters such as growth pattern, anterior chamber hyperintensity, and involvement of choroid, ciliary body, optic nerve, sclera, orbital fat, and pineal gland were determined. Tumor volume was measured and correlated to metastatic risk factors. Imaging and pathologic findings were compared. Statistical analysis was performed by using logistic regression with log likelihood ratio χ
    Original languageEnglish
    Pages (from-to)197-207
    Issue number1
    Publication statusPublished - 2005


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