Retrograde amnesia in patients with Alzheimer's disease

M. Meeter, E Eijsackers, J Mulder

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Abstract

Patients with mild to moderate Alzheimer's disease and normal controls were tested on two retrograde memory tests, one based on public events, and the other querying autobiographical memory. On both tests, patients showed strong decrements as compared to normal controls, pointing to retrograde amnesia. Evidence for a gradient in retrograde amnesia was conflicted, with analyses of variance revealing no gradient beyond the most recent period, and more sensitive analyses pointing to shallow Ribot gradients on both tests. A literature review shows that this is the case in most published studies. In autobiographical remote memory patients generated many incorrect answers, a tendency correlated with the number of false alarms on an anterograde memory test administered several months earlier. This suggests a stable, possibly executive, factor underlying memory errors. Copyright © Taylor & Francis Group, LLC.
Original languageEnglish
Pages (from-to)914-927
Number of pages15
JournalJournal of Clinical and Experimental Neuropsychology
Volume28
Issue number6
DOIs
Publication statusPublished - 2006

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