TY - JOUR
T1 - Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
AU - Gan, C.T.
AU - Holverda, S.
AU - Marcus, J.T.
AU - Paulus, W.J.S.
AU - Marques, K.M.
AU - Bronzwaer, J.G.F.
AU - Twisk, J.W.R.
AU - Boonstra, A.
AU - Postmus, P.E.
AU - Vonk Noordegraaf, A.
PY - 2007
Y1 - 2007
N2 - Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s
AB - Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s
U2 - 10.1378/chest.06-1263
DO - 10.1378/chest.06-1263
M3 - Article
SN - 0012-3692
VL - 132
SP - 11
EP - 17
JO - Chest
JF - Chest
ER -
