Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients

C.T. Gan; S. Holverda; J.T. Marcus; W.J.S. Paulus; K.M. Marques; J.G.F. Bronzwaer; J.W.R. Twisk; A. Boonstra; P.E. Postmus; A. Vonk Noordegraaf

doi:10.1378/chest.06-1263

Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients

C.T. Gan
, S. Holverda
, J.T. Marcus
, W.J.S. Paulus
, K.M. Marques
, J.G.F. Bronzwaer
, J.W.R. Twisk
, A. Boonstra
, P.E. Postmus
, A. Vonk Noordegraaf

Methodology and Applied Biostatistics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s

Original language	English
Pages (from-to)	11-17
Journal	Chest
Volume	132
DOIs	https://doi.org/10.1378/chest.06-1263
Publication status	Published - 2007

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1378/chest.06-1263

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title = "Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients",

abstract = "Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s",

author = "C.T. Gan and S. Holverda and J.T. Marcus and W.J.S. Paulus and K.M. Marques and J.G.F. Bronzwaer and J.W.R. Twisk and A. Boonstra and P.E. Postmus and \{Vonk Noordegraaf\}, A.",

year = "2007",

doi = "10.1378/chest.06-1263",

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T1 - Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients

AU - Gan, C.T.

AU - Holverda, S.

AU - Marcus, J.T.

AU - Paulus, W.J.S.

AU - Marques, K.M.

AU - Bronzwaer, J.G.F.

AU - Twisk, J.W.R.

AU - Boonstra, A.

AU - Postmus, P.E.

AU - Vonk Noordegraaf, A.

PY - 2007

Y1 - 2007

N2 - Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s

AB - Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s

U2 - 10.1378/chest.06-1263

DO - 10.1378/chest.06-1263

M3 - Article

SN - 0012-3692

VL - 132

SP - 11

EP - 17

JO - Chest

JF - Chest

ER -

Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients

Abstract

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