Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

E.M. Redout, M.J. Wagner, M.J. Zuidwijk, C. Boer, R.J.P. Musters, C. van Hardeveld, W.J.S. Paulus, W.S. Simonides

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp91
    Original languageEnglish
    Pages (from-to)770-781
    JournalCardiovascular Research
    Volume74
    DOIs
    Publication statusPublished - 2007

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