Risicofactoren voor het ontstaan van recidieven bij patiënten met een mammacarcinoom zonder okselkliermetastasen

Translated title of the contribution: Risk factors for the development of recurrences in patients with breast carcinoma without axillary lymph node metastases

W L Akkersdijk, J H Pieters, J G Smits, J T de Kruif, I van der Tweel, P W de Graaf

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The influence of a number of risk factors on development of tumour recurrence was studied retrospectively in a group of breast cancer patients without axillary lymph node metastases, all treated identically and with long follow-ups. Of 71 patients all data could be retrieved. This group had a median duration of follow-up of five years. Thirteen patients (18.3%) had had a recurrence of carcinoma after a median disease-free period of 41 months (range 3-124 months). These patients at the time when breast cancer was diagnosed had had a lower median age than patients who had remained free of tumour recurrence, 48 (40-70) as against 59.5 (30-81) years. Factors having a statistically significant prognostic importance for recurrence of tumour were age at the time of diagnosis of breast carcinoma, histological tumour grade and nuclear DNA content. Identifying groups of patients with a higher or lower risk of tumour recurrence appears possible by combination of risk factors. Although patients with breast cancer without axillary lymph node metastases are supposed to have a favourable prognosis, there appear to exist subgroups with a raised risk for development of a recurrence. These groups might be prime candidates for prospective randomized studies of the usefulness of adjuvant therapy.

Translated title of the contributionRisk factors for the development of recurrences in patients with breast carcinoma without axillary lymph node metastases
Original languageDutch
Pages (from-to)2391-5
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Volume137
Issue number46
Publication statusPublished - 13 Nov 1993

Keywords

  • Adult
  • Age Factors
  • Aged
  • Breast Neoplasms
  • DNA, Neoplasm
  • Female
  • Humans
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • English Abstract
  • Journal Article

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