Risicofactoren voor het ontstaan van recidieven bij patiënten met een mammacarcinoom zonder okselkliermetastasen

Translated title of the contribution: Risk factors for the development of recurrences in patients with breast carcinoma without axillary lymph node metastases

W L Akkersdijk, J H Pieters, J G Smits, J T de Kruif, I van der Tweel, P W de Graaf

Research output: Contribution to JournalArticleAcademicpeer-review


The influence of a number of risk factors on development of tumour recurrence was studied retrospectively in a group of breast cancer patients without axillary lymph node metastases, all treated identically and with long follow-ups. Of 71 patients all data could be retrieved. This group had a median duration of follow-up of five years. Thirteen patients (18.3%) had had a recurrence of carcinoma after a median disease-free period of 41 months (range 3-124 months). These patients at the time when breast cancer was diagnosed had had a lower median age than patients who had remained free of tumour recurrence, 48 (40-70) as against 59.5 (30-81) years. Factors having a statistically significant prognostic importance for recurrence of tumour were age at the time of diagnosis of breast carcinoma, histological tumour grade and nuclear DNA content. Identifying groups of patients with a higher or lower risk of tumour recurrence appears possible by combination of risk factors. Although patients with breast cancer without axillary lymph node metastases are supposed to have a favourable prognosis, there appear to exist subgroups with a raised risk for development of a recurrence. These groups might be prime candidates for prospective randomized studies of the usefulness of adjuvant therapy.

Original languageDutch
Pages (from-to)2391-5
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Issue number46
Publication statusPublished - 13 Nov 1993



  • Adult
  • Age Factors
  • Aged
  • Breast Neoplasms
  • DNA, Neoplasm
  • Female
  • Humans
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • English Abstract
  • Journal Article

Cite this

Akkersdijk, W. L., Pieters, J. H., Smits, J. G., de Kruif, J. T., van der Tweel, I., & de Graaf, P. W. (1993). Risicofactoren voor het ontstaan van recidieven bij patiënten met een mammacarcinoom zonder okselkliermetastasen. Nederlands Tijdschrift voor Geneeskunde, 137(46), 2391-5.