Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing

M. Holtje, A. Hoffmann, F. Hofmann, C. Mucke, G. Grosse, N. van Rooijen, H. Kettenmann, I. Just, G. Ahnert-Hilger

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells. Rho function mediates morphological changes as well as locomotor activity. Using astrocyte cultures established from neonatal mice we investigated the role of Rho in process formation during astrocyte stellation. Using a scratch-wound model, we examined the impact of Rho on a variety of morphological and functional variables such as stellation and migratory activity during wound healing. C3 proteins are widely used to study cellular Rho functions. In addition, C3 derived from Clostridlum botulinum (C3
Original languageEnglish
Pages (from-to)1237-1248
JournalJournal of Neurochemistry
Volume95
Issue number5
DOIs
Publication statusPublished - 2005

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