Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing

M. Holtje; A. Hoffmann; F. Hofmann; C. Mucke; G. Grosse; N. van Rooijen; H. Kettenmann; I. Just; G. Ahnert-Hilger

doi:10.1111/j.1471-4159.2005.03443.x

Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing

M. Holtje
, A. Hoffmann
, F. Hofmann
, C. Mucke
, G. Grosse
, N. van Rooijen
, H. Kettenmann
, I. Just
, G. Ahnert-Hilger

School of Religion and Theology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells. Rho function mediates morphological changes as well as locomotor activity. Using astrocyte cultures established from neonatal mice we investigated the role of Rho in process formation during astrocyte stellation. Using a scratch-wound model, we examined the impact of Rho on a variety of morphological and functional variables such as stellation and migratory activity during wound healing. C3 proteins are widely used to study cellular Rho functions. In addition, C3 derived from Clostridlum botulinum (C3

Original language	English
Pages (from-to)	1237-1248
Journal	Journal of Neurochemistry
Volume	95
Issue number	5
DOIs	https://doi.org/10.1111/j.1471-4159.2005.03443.x
Publication status	Published - 2005

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SDG 3 Good Health and Well-being

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10.1111/j.1471-4159.2005.03443.x

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title = "Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing",

abstract = "Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells. Rho function mediates morphological changes as well as locomotor activity. Using astrocyte cultures established from neonatal mice we investigated the role of Rho in process formation during astrocyte stellation. Using a scratch-wound model, we examined the impact of Rho on a variety of morphological and functional variables such as stellation and migratory activity during wound healing. C3 proteins are widely used to study cellular Rho functions. In addition, C3 derived from Clostridlum botulinum (C3",

author = "M. Holtje and A. Hoffmann and F. Hofmann and C. Mucke and G. Grosse and \{van Rooijen\}, N. and H. Kettenmann and I. Just and G. Ahnert-Hilger",

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TY - JOUR

T1 - Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing

AU - Holtje, M.

AU - Hoffmann, A.

AU - Hofmann, F.

AU - Mucke, C.

AU - Grosse, G.

AU - van Rooijen, N.

AU - Kettenmann, H.

AU - Just, I.

AU - Ahnert-Hilger, G.

PY - 2005

Y1 - 2005

N2 - Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells. Rho function mediates morphological changes as well as locomotor activity. Using astrocyte cultures established from neonatal mice we investigated the role of Rho in process formation during astrocyte stellation. Using a scratch-wound model, we examined the impact of Rho on a variety of morphological and functional variables such as stellation and migratory activity during wound healing. C3 proteins are widely used to study cellular Rho functions. In addition, C3 derived from Clostridlum botulinum (C3

AB - Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells. Rho function mediates morphological changes as well as locomotor activity. Using astrocyte cultures established from neonatal mice we investigated the role of Rho in process formation during astrocyte stellation. Using a scratch-wound model, we examined the impact of Rho on a variety of morphological and functional variables such as stellation and migratory activity during wound healing. C3 proteins are widely used to study cellular Rho functions. In addition, C3 derived from Clostridlum botulinum (C3

U2 - 10.1111/j.1471-4159.2005.03443.x

DO - 10.1111/j.1471-4159.2005.03443.x

M3 - Article

SN - 0022-3042

VL - 95

SP - 1237

EP - 1248

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 5

ER -

Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing

Abstract

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