S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations

A. Becker; Y.M. Smulders; T. Teerlink; E.A. Struys; K. de Meer; P.J. Kostense; C. Jakobs; J.M. Dekker; G. Nijpels; R.J. Heine; L.M. Bouter; C.D.A. Stehouwer

doi:10.1046/j.1365-2362.2003.01104.x

S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations

A. Becker
, Y.M. Smulders
, T. Teerlink
, E.A. Struys
, K. de Meer
, P.J. Kostense
, C. Jakobs
, J.M. Dekker
, G. Nijpels
, R.J. Heine
, L.M. Bouter
, C.D.A. Stehouwer

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

Background: It is unclear whether homocysteine itself is causal in the pathogenesis of cardiovascular disease. Alternatively or additionally, the association between homocysteine and cardiovascular disease may be because of its metabolic precursor, S-adenosylhomocysteine, or of the ratio of S-adenosylmethionine to S-adenosylhomocysteine. Therefore, it is relevant to know how these moieties are interrelated, and whether, as is the case for homocysteine, they are influenced by blood levels of folate, cobalamin or vitamin B

Original language	English
Pages (from-to)	17-25
Number of pages	9
Journal	European Journal of Clinical Investigation
Volume	33
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2362.2003.01104.x
Publication status	Published - 2003

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SDG 3 Good Health and Well-being

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Becker, A., Smulders, Y. M., Teerlink, T., Struys, E. A., de Meer, K., Kostense, P. J., Jakobs, C., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., & Stehouwer, C. D. A. (2003). S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations. European Journal of Clinical Investigation, 33(1), 17-25. https://doi.org/10.1046/j.1365-2362.2003.01104.x

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title = "S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations",

abstract = "Background: It is unclear whether homocysteine itself is causal in the pathogenesis of cardiovascular disease. Alternatively or additionally, the association between homocysteine and cardiovascular disease may be because of its metabolic precursor, S-adenosylhomocysteine, or of the ratio of S-adenosylmethionine to S-adenosylhomocysteine. Therefore, it is relevant to know how these moieties are interrelated, and whether, as is the case for homocysteine, they are influenced by blood levels of folate, cobalamin or vitamin B",

author = "A. Becker and Y.M. Smulders and T. Teerlink and E.A. Struys and \{de Meer\}, K. and P.J. Kostense and C. Jakobs and J.M. Dekker and G. Nijpels and R.J. Heine and L.M. Bouter and C.D.A. Stehouwer",

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doi = "10.1046/j.1365-2362.2003.01104.x",

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Becker, A, Smulders, YM, Teerlink, T, Struys, EA, de Meer, K, Kostense, PJ, Jakobs, C, Dekker, JM, Nijpels, G, Heine, RJ, Bouter, LM & Stehouwer, CDA 2003, 'S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations', European Journal of Clinical Investigation, vol. 33, no. 1, pp. 17-25. https://doi.org/10.1046/j.1365-2362.2003.01104.x

TY - JOUR

T1 - S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations

AU - Becker, A.

AU - Smulders, Y.M.

AU - Teerlink, T.

AU - Struys, E.A.

AU - de Meer, K.

AU - Kostense, P.J.

AU - Jakobs, C.

AU - Dekker, J.M.

AU - Nijpels, G.

AU - Heine, R.J.

AU - Bouter, L.M.

AU - Stehouwer, C.D.A.

PY - 2003

Y1 - 2003

N2 - Background: It is unclear whether homocysteine itself is causal in the pathogenesis of cardiovascular disease. Alternatively or additionally, the association between homocysteine and cardiovascular disease may be because of its metabolic precursor, S-adenosylhomocysteine, or of the ratio of S-adenosylmethionine to S-adenosylhomocysteine. Therefore, it is relevant to know how these moieties are interrelated, and whether, as is the case for homocysteine, they are influenced by blood levels of folate, cobalamin or vitamin B

AB - Background: It is unclear whether homocysteine itself is causal in the pathogenesis of cardiovascular disease. Alternatively or additionally, the association between homocysteine and cardiovascular disease may be because of its metabolic precursor, S-adenosylhomocysteine, or of the ratio of S-adenosylmethionine to S-adenosylhomocysteine. Therefore, it is relevant to know how these moieties are interrelated, and whether, as is the case for homocysteine, they are influenced by blood levels of folate, cobalamin or vitamin B

UR - https://www.scopus.com/pages/publications/12244286742

UR - https://www.scopus.com/pages/publications/12244286742#tab=citedBy

U2 - 10.1046/j.1365-2362.2003.01104.x

DO - 10.1046/j.1365-2362.2003.01104.x

M3 - Article

SN - 0014-2972

VL - 33

SP - 17

EP - 25

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 1

ER -

S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations

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