Salivary biomarkers of stress and inflammation in first graders in Côte d′Ivoire: Effects of a probiotic food intervention

Bonnie E. Brett; Bruno K. Koko; Habib O.Y. Doumbia; Frédéric Kouadio Koffi; Savorgnan E. Assa; Kollet Y.A.S. Zahé; Hortense Faye-Ketté; Séraphin Kati-Coulibaly; Remco Kort; Wilbert Sybesma; Gregor Reid; Carolina de Weerth

doi:10.1016/j.psyneuen.2021.105255

Salivary biomarkers of stress and inflammation in first graders in Côte d′Ivoire: Effects of a probiotic food intervention

Bonnie E. Brett^*, Bruno K. Koko, Habib O.Y. Doumbia, Frédéric Kouadio Koffi, Savorgnan E. Assa, Kollet Y.A.S. Zahé, Hortense Faye-Ketté, Séraphin Kati-Coulibaly, Remco Kort, Wilbert Sybesma, Gregor Reid, Carolina de Weerth

^*Corresponding author for this work

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and C-reactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economically-disadvantaged schools in an urban setting in Côte d′Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p =.015); CRP levels were comparable across groups (p =.549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.

Original language	English
Article number	105255
Pages (from-to)	1-8
Number of pages	8
Journal	Psychoneuroendocrinology
Volume	129
Early online date	12 May 2021
DOIs	https://doi.org/10.1016/j.psyneuen.2021.105255
Publication status	Published - Jul 2021

Bibliographical note

Funding Information:
This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research ( 016. Vici. 185.038 ) to C. de Weerth.

Funding Information:
This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research (016. Vici. 185.038) to C. de Weerth.

Publisher Copyright:
© 2021 The Authors

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Funding

This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research ( 016. Vici. 185.038 ) to C. de Weerth. This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research (016. Vici. 185.038) to C. de Weerth.

Funders	Funder number
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	185.038
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Jacobs Foundation

Keywords

C-reactive protein
Cortisol
Food supplement
Inflammation
Probiotic
Stress

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10.1016/j.psyneuen.2021.105255

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Brett, B. E., Koko, B. K., Doumbia, H. O. Y., Koffi, F. K., Assa, S. E., Zahé, K. Y. A. S., Faye-Ketté, H., Kati-Coulibaly, S., Kort, R., Sybesma, W., Reid, G., & de Weerth, C. (2021). Salivary biomarkers of stress and inflammation in first graders in Côte d′Ivoire: Effects of a probiotic food intervention. Psychoneuroendocrinology, 129, 1-8. Article 105255. https://doi.org/10.1016/j.psyneuen.2021.105255

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abstract = "This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and C-reactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economically-disadvantaged schools in an urban setting in C{\^o}te d′Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p =.015); CRP levels were comparable across groups (p =.549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.",

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author = "Brett, {Bonnie E.} and Koko, {Bruno K.} and Doumbia, {Habib O.Y.} and Koffi, {Fr{\'e}d{\'e}ric Kouadio} and Assa, {Savorgnan E.} and Zah{\'e}, {Kollet Y.A.S.} and Hortense Faye-Kett{\'e} and S{\'e}raphin Kati-Coulibaly and Remco Kort and Wilbert Sybesma and Gregor Reid and {de Weerth}, Carolina",

note = "Funding Information: This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research ( 016. Vici. 185.038 ) to C. de Weerth. Funding Information: This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research (016. Vici. 185.038) to C. de Weerth. Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jul,

doi = "10.1016/j.psyneuen.2021.105255",

language = "English",

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Brett, BE, Koko, BK, Doumbia, HOY, Koffi, FK, Assa, SE, Zahé, KYAS, Faye-Ketté, H, Kati-Coulibaly, S, Kort, R, Sybesma, W, Reid, G & de Weerth, C 2021, 'Salivary biomarkers of stress and inflammation in first graders in Côte d′Ivoire: Effects of a probiotic food intervention', Psychoneuroendocrinology, vol. 129, 105255, pp. 1-8. https://doi.org/10.1016/j.psyneuen.2021.105255

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T2 - Effects of a probiotic food intervention

AU - Brett, Bonnie E.

AU - Koko, Bruno K.

AU - Doumbia, Habib O.Y.

AU - Koffi, Frédéric Kouadio

AU - Assa, Savorgnan E.

AU - Zahé, Kollet Y.A.S.

AU - Faye-Ketté, Hortense

AU - Kati-Coulibaly, Séraphin

AU - Kort, Remco

AU - Sybesma, Wilbert

AU - Reid, Gregor

AU - de Weerth, Carolina

N1 - Funding Information: This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research ( 016. Vici. 185.038 ) to C. de Weerth. Funding Information: This work was supported by a Jacobs Foundation Advanced Research Fellowship and a personal VICI grant from the Netherlands Organization for Scientific Research (016. Vici. 185.038) to C. de Weerth. Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/7

Y1 - 2021/7

N2 - This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and C-reactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economically-disadvantaged schools in an urban setting in Côte d′Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p =.015); CRP levels were comparable across groups (p =.549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.

AB - This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and C-reactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economically-disadvantaged schools in an urban setting in Côte d′Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p =.015); CRP levels were comparable across groups (p =.549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.

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KW - Food supplement

KW - Inflammation

KW - Probiotic

KW - Stress

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JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

M1 - 105255

ER -

Salivary biomarkers of stress and inflammation in first graders in Côte d′Ivoire: Effects of a probiotic food intervention

Abstract

Bibliographical note

Funding

Keywords

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