Schizophrenia genetic variants are not associated with intelligence

A.F. Terwisscha van Scheltinga, S.C. Bakker, N.E. van Haren, E.M. Derks, J.E. Buizer-Voskamp, W. Cahn, S. Ripke, R.A. Ophoff, D. Posthuma, R.S. Kahn

Research output: Contribution to JournalArticleAcademicpeer-review


Background Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence. Method IQ was estimated with the Wechsler Adult Intelligence Scale (WAIS). CNVs were determined from single nucleotide polymorphism (SNP) data using the QuantiSNP and PennCNV algorithms. For the PSS, odds ratios for genome-wide SNP data were calculated in a sample collected by the Psychiatric Genome-Wide Association Study (GWAS) Consortium (8690 schizophrenia patients and 11 831 controls). These were used to calculate individual PSSs in our independent sample of 350 schizophrenia patients and 322 healthy controls. Results Although significantly more genes were disrupted by deletions in schizophrenia patients compared to controls (p = 0.009), there was no effect of CNV measures on IQ. The PSS was associated with disease status (R
Original languageEnglish
Pages (from-to)2563-2570
JournalPsychological Medicine
Issue number12
Publication statusPublished - 2013

Bibliographical note

Psychiatric Genome-Wide Association Study (GWAS) Consortium,


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