Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system

F.A. Court, W.T.J. Hendriks, H.D. Mac Gillavry, J. Alvarez, J. van Minnen

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Abstract

Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis. Copyright © 2008 Society for Neuroscience.
Original languageEnglish
Pages (from-to)11024-11029
Number of pages6
JournalThe Journal of Neuroscience
Volume28
DOIs
Publication statusPublished - 2008

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