Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis. Copyright © 2008 Society for Neuroscience.
Court, F. A., Hendriks, W. T. J., Mac Gillavry, H. D., Alvarez, J., & van Minnen, J. (2008). Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system. The Journal of Neuroscience, 28, 11024-11029. https://doi.org/10.1523/JNEUROSCI.2429-08.2008