TY - JOUR
T1 - Scratching the surface: Exploratory analysis of key opinion leaders on rate limiting factors in novel adjuvanted-vaccine
AU - Pronker, E.S.
AU - Claassen, E.
AU - Weenen, T
AU - Commandeur, H
AU - Osterhaus, A.D.M.E.
PY - 2015
Y1 - 2015
N2 - This exploratory qualitative article analyzes the potentially rate-limiting factors affecting value chain dynamics during adjuvanted-vaccine development. Adjuvants are considered immunostimulating substances that can be added to a vaccine. Although adjuvants have the potential to elicit adverse reactions, they also offer certain benefits. After approximately 90 years of R&D, why have only four adjuvants been approved? Although ample literature is available describing the risks and benefits, it remains unclear as to how these potentially rate-limiting factors compare. Experts - representing knowledge institutes, industry and regulatory/public health authorities - were approached in order to collect a unique weighted-ranking dataset on rate limiting factors. Based on the principal-agent theory, there is a partial conflict of interests between the internal perceptions on the challenges faced. Additionally, content analysis reveals four underlying social constructs influencing this perception, namely: attitudes towards risk management, innovation strategy, valuation and funding. This study was designed to explore the topic of rate-limiting factors, and not intended to solve the issues. Moreover we offer previously unpublished and practical insights on the topic, and offer a validated starting point for further research. Ultimately, we would advocate more transparency on reasons for project discontinuation; sharing lessons learned from failed attempts could prove valuable for advancing the field of virosciences. © 2014 Elsevier Inc. All rights reserved.
AB - This exploratory qualitative article analyzes the potentially rate-limiting factors affecting value chain dynamics during adjuvanted-vaccine development. Adjuvants are considered immunostimulating substances that can be added to a vaccine. Although adjuvants have the potential to elicit adverse reactions, they also offer certain benefits. After approximately 90 years of R&D, why have only four adjuvants been approved? Although ample literature is available describing the risks and benefits, it remains unclear as to how these potentially rate-limiting factors compare. Experts - representing knowledge institutes, industry and regulatory/public health authorities - were approached in order to collect a unique weighted-ranking dataset on rate limiting factors. Based on the principal-agent theory, there is a partial conflict of interests between the internal perceptions on the challenges faced. Additionally, content analysis reveals four underlying social constructs influencing this perception, namely: attitudes towards risk management, innovation strategy, valuation and funding. This study was designed to explore the topic of rate-limiting factors, and not intended to solve the issues. Moreover we offer previously unpublished and practical insights on the topic, and offer a validated starting point for further research. Ultimately, we would advocate more transparency on reasons for project discontinuation; sharing lessons learned from failed attempts could prove valuable for advancing the field of virosciences. © 2014 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.techfore.2014.04.017
DO - 10.1016/j.techfore.2014.04.017
M3 - Article
SN - 0040-1625
VL - 90
SP - 420
EP - 432
JO - Technological Forecasting and Social Change
JF - Technological Forecasting and Social Change
IS - B
ER -
