Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Jacobo Gómez-González; Laura Martínez-Castro; Juan Tolosa-Barrilero; Ana Alcalde-Ordóñez; Soraya Learte-Aymamí; José L. Mascareñas; Joaquín C. García-Martínez; José Martínez-Costas; Jean-Didier Maréchal; Miguel Vázquez López; M. Eugenio Vázquez

doi:10.1039/d2cc02874c

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Jacobo Gómez-González
, Laura Martínez-Castro
, Juan Tolosa-Barrilero
, Ana Alcalde-Ordóñez
, Soraya Learte-Aymamí
, José L. Mascareñas
, Joaquín C. García-Martínez
, José Martínez-Costas
, Jean-Didier Maréchal
, Miguel Vázquez López
, M. Eugenio Vázquez

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

Original language	English
Pages (from-to)	7769-7772
Journal	Chemical Communications
Volume	58
Issue number	56
DOIs	https://doi.org/10.1039/d2cc02874c
Publication status	Published - 22 Jun 2022
Externally published	Yes

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10.1039/d2cc02874c

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Gómez-González, J., Martínez-Castro, L., Tolosa-Barrilero, J., Alcalde-Ordóñez, A., Learte-Aymamí, S., Mascareñas, J. L., García-Martínez, J. C., Martínez-Costas, J., Maréchal, J.-D., Vázquez López, M., & Vázquez, M. E. (2022). Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide. Chemical Communications, 58(56), 7769-7772. https://doi.org/10.1039/d2cc02874c

@article{188b0194ca294606a0e7143ba795ff03,

title = "Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide",

abstract = "Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.",

author = "Jacobo G{\'o}mez-Gonz{\'a}lez and Laura Mart{\'i}nez-Castro and Juan Tolosa-Barrilero and Ana Alcalde-Ord{\'o}{\~n}ez and Soraya Learte-Aymam{\'i} and Mascare{\~n}as, \{Jos{\'e} L.\} and Garc{\'i}a-Mart{\'i}nez, \{Joaqu{\'i}n C.\} and Jos{\'e} Mart{\'i}nez-Costas and Jean-Didier Mar{\'e}chal and \{V{\'a}zquez L{\'o}pez\}, Miguel and V{\'a}zquez, \{M. Eugenio\}",

year = "2022",

month = jun,

day = "22",

doi = "10.1039/d2cc02874c",

language = "English",

volume = "58",

pages = "7769--7772",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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}

Gómez-González, J, Martínez-Castro, L, Tolosa-Barrilero, J, Alcalde-Ordóñez, A, Learte-Aymamí, S, Mascareñas, JL, García-Martínez, JC, Martínez-Costas, J, Maréchal, J-D, Vázquez López, M & Vázquez, ME 2022, 'Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide', Chemical Communications, vol. 58, no. 56, pp. 7769-7772. https://doi.org/10.1039/d2cc02874c

TY - JOUR

T1 - Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

AU - Gómez-González, Jacobo

AU - Martínez-Castro, Laura

AU - Tolosa-Barrilero, Juan

AU - Alcalde-Ordóñez, Ana

AU - Learte-Aymamí, Soraya

AU - Mascareñas, José L.

AU - García-Martínez, Joaquín C.

AU - Martínez-Costas, José

AU - Maréchal, Jean-Didier

AU - Vázquez López, Miguel

AU - Vázquez, M. Eugenio

PY - 2022/6/22

Y1 - 2022/6/22

N2 - Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

AB - Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

UR - https://www.scopus.com/pages/publications/85132858790

UR - https://www.scopus.com/pages/publications/85132858790#tab=citedBy

U2 - 10.1039/d2cc02874c

DO - 10.1039/d2cc02874c

M3 - Article

SN - 1359-7345

VL - 58

SP - 7769

EP - 7772

JO - Chemical Communications

JF - Chemical Communications

IS - 56

ER -

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

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