Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

N. Lozovaya; S. Gataullina; T. Tsintsadze; V. Tsintsadze; E. Pallesi-Pocachard; M. Minlebaev; N.A. Goriounova; E. Buhler; F. Watrin; S. Shityakov; A.J. Becker; A. Bordey; M. Milh; D. Scavarda; C. Bulteau; G. Dorfmuller; O. Delalande; A. Represa; C. Cardoso; O. Dulac; Y. Ben-Ari; N. Burnashev

doi:10.1038/ncomms5563

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

N. Lozovaya, S. Gataullina, T. Tsintsadze, V. Tsintsadze, E. Pallesi-Pocachard, M. Minlebaev, N.A. Goriounova, E. Buhler, F. Watrin, S. Shityakov, A.J. Becker, A. Bordey, M. Milh, D. Scavarda, C. Bulteau, G. Dorfmuller, O. Delalande, A. Represa, C. Cardoso, O. DulacY. Ben-Ari, N. Burnashev

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote Tsc1

Original language	English
Article number	4563
Pages (from-to)	4563
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5563
Publication status	Published - 2014

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Lozovaya, N., Gataullina, S., Tsintsadze, T., Tsintsadze, V., Pallesi-Pocachard, E., Minlebaev, M., Goriounova, N. A., Buhler, E., Watrin, F., Shityakov, S., Becker, A. J., Bordey, A., Milh, M., Scavarda, D., Bulteau, C., Dorfmuller, G., Delalande, O., Represa, A., Cardoso, C., ... Burnashev, N. (2014). Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nature Communications, 5, 4563. Article 4563. https://doi.org/10.1038/ncomms5563

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title = "Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.",

abstract = "Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote Tsc1",

author = "N. Lozovaya and S. Gataullina and T. Tsintsadze and V. Tsintsadze and E. Pallesi-Pocachard and M. Minlebaev and N.A. Goriounova and E. Buhler and F. Watrin and S. Shityakov and A.J. Becker and A. Bordey and M. Milh and D. Scavarda and C. Bulteau and G. Dorfmuller and O. Delalande and A. Represa and C. Cardoso and O. Dulac and Y. Ben-Ari and N. Burnashev",

year = "2014",

doi = "10.1038/ncomms5563",

language = "English",

volume = "5",

pages = "4563",

journal = "Nature Communications",

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Lozovaya, N, Gataullina, S, Tsintsadze, T, Tsintsadze, V, Pallesi-Pocachard, E, Minlebaev, M, Goriounova, NA, Buhler, E, Watrin, F, Shityakov, S, Becker, AJ, Bordey, A, Milh, M, Scavarda, D, Bulteau, C, Dorfmuller, G, Delalande, O, Represa, A, Cardoso, C, Dulac, O, Ben-Ari, Y & Burnashev, N 2014, 'Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.', Nature Communications, vol. 5, 4563, pp. 4563. https://doi.org/10.1038/ncomms5563

TY - JOUR

T1 - Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

AU - Lozovaya, N.

AU - Gataullina, S.

AU - Tsintsadze, T.

AU - Tsintsadze, V.

AU - Pallesi-Pocachard, E.

AU - Minlebaev, M.

AU - Goriounova, N.A.

AU - Buhler, E.

AU - Watrin, F.

AU - Shityakov, S.

AU - Becker, A.J.

AU - Bordey, A.

AU - Milh, M.

AU - Scavarda, D.

AU - Bulteau, C.

AU - Dorfmuller, G.

AU - Delalande, O.

AU - Represa, A.

AU - Cardoso, C.

AU - Dulac, O.

AU - Ben-Ari, Y.

AU - Burnashev, N.

PY - 2014

Y1 - 2014

N2 - Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote Tsc1

AB - Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote Tsc1

U2 - 10.1038/ncomms5563

DO - 10.1038/ncomms5563

M3 - Article

SN - 2041-1723

VL - 5

SP - 4563

JO - Nature Communications

JF - Nature Communications

M1 - 4563

ER -

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

Abstract

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