Sensitivity analysis of Raman endoscopy with and without wavefront shaping

Lyubov V. Amitonova*, Johannes F. de Boer

*Corresponding author for this work

Research output: Contribution to JournalArticle

Abstract

Vibrational spectroscopy is a powerful method for the label-free identification of molecules. Spontaneous Raman spectroscopy integrated with an ultra-thin fiber-based endoscope can provide remote, local, and minimally invasive chemical analysis in many fields from biomedical diagnostics to the materials industry. Miniaturization of the probe in combination with a large field of view (FOV) and high sensitivity would be beneficial for a broad class of applications. Here we quantitatively analyze signal-to-noise ratio (SNR) and the sensitivity improvement due to wavefront shaping. We show that wavefront shaping in an ultra-thin single-fiber probe allows to decrease the total measurements time up to several orders of magnitude even without any prior knowledge of the Raman particle location. Such a fiber probe is well suited for minimally-invasive endoscopy in biological and medical applications.

Original languageEnglish
Pages (from-to)3779-3788
Number of pages10
JournalOptics Express
Volume28
Issue number3
Early online date27 Jan 2020
DOIs
Publication statusPublished - 3 Feb 2020

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