Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis

M.H.G.M. van der Pas, S. Meijer, O.S. Hoekstra, I. Riphagen, H.C.W. de Vet, D.L. Knol, N.C.T. van Grieken, W.J.H.J. Meijerink

    Research output: Contribution to JournalArticleAcademicpeer-review


    Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ
    Original languageEnglish
    Pages (from-to)540-550
    JournalLancet Oncology
    Issue number6
    Publication statusPublished - 2011


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