TY - JOUR
T1 - Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis
AU - van der Pas, M.H.G.M.
AU - Meijer, S.
AU - Hoekstra, O.S.
AU - Riphagen, I.
AU - de Vet, H.C.W.
AU - Knol, D.L.
AU - van Grieken, N.C.T.
AU - Meijerink, W.J.H.J.
PY - 2011
Y1 - 2011
N2 - Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ
AB - Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ
UR - https://www.scopus.com/pages/publications/79957510776
UR - https://www.scopus.com/inward/citedby.url?scp=79957510776&partnerID=8YFLogxK
U2 - 10.1016/S1470-2045(11)70075-4
DO - 10.1016/S1470-2045(11)70075-4
M3 - Article
SN - 1470-2045
VL - 12
SP - 540
EP - 550
JO - The Lancet Oncology
JF - The Lancet Oncology
IS - 6
ER -
