Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

M.A.R. Ferreira; J.J. Hottenga; N.M. Warrington; S.E. Medland; G. Willemsen; R.W. Lawrence; S. Gordon; E.J.C. de Geus; A.K. Henders; J. H. Smit; M.J. Campbell; L. Wallace; D.M. Evans; M.J. Wright; DR Nyholt; A.L. James; J.P. Beilby; B.W.J.H. Penninx; L.J. Palmer; I.H. Frazer; GW Montgomery; N.G. Martin; D.I. Boomsma

doi:10.1016/j.ajhg.2009.10.005

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

M.A.R. Ferreira, J.J. Hottenga, N.M. Warrington, S.E. Medland, G. Willemsen, R.W. Lawrence, S. Gordon, E.J.C. de Geus, A.K. Henders, J. H. Smit, M.J. Campbell, L. Wallace, D.M. Evans, M.J. Wright, DR Nyholt, A.L. James, J.P. Beilby, B.W.J.H. Penninx, L.J. Palmer, I.H. FrazerGW Montgomery, N.G. Martin, D.I. Boomsma

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Blood cells participate in vital physiological processes, and their numbers are tightly regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms underlies many blood-related Mendelian diseases but also contributes to more common disorders, including atherosclerosis. We searched for quantitative trait loci (QTL) for hematology traits through a whole-genome association study, because these could provide new insights into both hemopoeitic and disease mechanisms. We tested 1.8 million variants for association with 13 hematology traits measured in 6015 individuals from the Australian and Dutch populations. These traits included hemoglobin composition, platelet counts, and red blood cell and white blood cell indices. We identified three regions of strong association that, to our knowledge, have not been previously reported in the literature. The first was located in an intergenic region of chromosome 9q31 near LPAR1, explaining 1.5% of the variation in monocyte counts (best SNP rs7023923, p = 8.9 × 10

Original language	English
Pages (from-to)	745-749
Journal	American Journal of Human Genetics
Volume	85
Issue number	5
DOIs	https://doi.org/10.1016/j.ajhg.2009.10.005
Publication status	Published - 2009

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajhg.2009.10.005

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR-publicaties_2009/Ferreira_AJHG_2009.pdf

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Ferreira, M. A. R., Hottenga, J. J., Warrington, N. M., Medland, S. E., Willemsen, G., Lawrence, R. W., Gordon, S., de Geus, E. J. C., Henders, A. K., Smit, J. H., Campbell, M. J., Wallace, L., Evans, D. M., Wright, M. J., Nyholt, DR., James, A. L., Beilby, J. P., Penninx, B. W. J. H., Palmer, L. J., ... Boomsma, D. I. (2009). Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume. American Journal of Human Genetics, 85(5), 745-749. https://doi.org/10.1016/j.ajhg.2009.10.005

@article{0e290f0f2e5c483bb0bb1cf9a7ba17bf,

title = "Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume",

abstract = "Blood cells participate in vital physiological processes, and their numbers are tightly regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms underlies many blood-related Mendelian diseases but also contributes to more common disorders, including atherosclerosis. We searched for quantitative trait loci (QTL) for hematology traits through a whole-genome association study, because these could provide new insights into both hemopoeitic and disease mechanisms. We tested 1.8 million variants for association with 13 hematology traits measured in 6015 individuals from the Australian and Dutch populations. These traits included hemoglobin composition, platelet counts, and red blood cell and white blood cell indices. We identified three regions of strong association that, to our knowledge, have not been previously reported in the literature. The first was located in an intergenic region of chromosome 9q31 near LPAR1, explaining 1.5% of the variation in monocyte counts (best SNP rs7023923, p = 8.9 × 10",

author = "M.A.R. Ferreira and J.J. Hottenga and N.M. Warrington and S.E. Medland and G. Willemsen and R.W. Lawrence and S. Gordon and {de Geus}, E.J.C. and A.K. Henders and Smit, {J. H.} and M.J. Campbell and L. Wallace and D.M. Evans and M.J. Wright and DR Nyholt and A.L. James and J.P. Beilby and B.W.J.H. Penninx and L.J. Palmer and I.H. Frazer and GW Montgomery and N.G. Martin and D.I. Boomsma",

year = "2009",

doi = "10.1016/j.ajhg.2009.10.005",

language = "English",

volume = "85",

pages = "745--749",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "5",

}

Ferreira, MAR, Hottenga, JJ, Warrington, NM, Medland, SE, Willemsen, G, Lawrence, RW, Gordon, S, de Geus, EJC, Henders, AK, Smit, JH, Campbell, MJ, Wallace, L, Evans, DM, Wright, MJ, Nyholt, DR, James, AL, Beilby, JP, Penninx, BWJH, Palmer, LJ, Frazer, IH, Montgomery, GW, Martin, NG & Boomsma, DI 2009, 'Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume', American Journal of Human Genetics, vol. 85, no. 5, pp. 745-749. https://doi.org/10.1016/j.ajhg.2009.10.005

TY - JOUR

T1 - Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

AU - Ferreira, M.A.R.

AU - Hottenga, J.J.

AU - Warrington, N.M.

AU - Medland, S.E.

AU - Willemsen, G.

AU - Lawrence, R.W.

AU - Gordon, S.

AU - de Geus, E.J.C.

AU - Henders, A.K.

AU - Smit, J. H.

AU - Campbell, M.J.

AU - Wallace, L.

AU - Evans, D.M.

AU - Wright, M.J.

AU - Nyholt, DR

AU - James, A.L.

AU - Beilby, J.P.

AU - Penninx, B.W.J.H.

AU - Palmer, L.J.

AU - Frazer, I.H.

AU - Montgomery, GW

AU - Martin, N.G.

AU - Boomsma, D.I.

PY - 2009

Y1 - 2009

N2 - Blood cells participate in vital physiological processes, and their numbers are tightly regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms underlies many blood-related Mendelian diseases but also contributes to more common disorders, including atherosclerosis. We searched for quantitative trait loci (QTL) for hematology traits through a whole-genome association study, because these could provide new insights into both hemopoeitic and disease mechanisms. We tested 1.8 million variants for association with 13 hematology traits measured in 6015 individuals from the Australian and Dutch populations. These traits included hemoglobin composition, platelet counts, and red blood cell and white blood cell indices. We identified three regions of strong association that, to our knowledge, have not been previously reported in the literature. The first was located in an intergenic region of chromosome 9q31 near LPAR1, explaining 1.5% of the variation in monocyte counts (best SNP rs7023923, p = 8.9 × 10

AB - Blood cells participate in vital physiological processes, and their numbers are tightly regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms underlies many blood-related Mendelian diseases but also contributes to more common disorders, including atherosclerosis. We searched for quantitative trait loci (QTL) for hematology traits through a whole-genome association study, because these could provide new insights into both hemopoeitic and disease mechanisms. We tested 1.8 million variants for association with 13 hematology traits measured in 6015 individuals from the Australian and Dutch populations. These traits included hemoglobin composition, platelet counts, and red blood cell and white blood cell indices. We identified three regions of strong association that, to our knowledge, have not been previously reported in the literature. The first was located in an intergenic region of chromosome 9q31 near LPAR1, explaining 1.5% of the variation in monocyte counts (best SNP rs7023923, p = 8.9 × 10

U2 - 10.1016/j.ajhg.2009.10.005

DO - 10.1016/j.ajhg.2009.10.005

M3 - Article

SN - 0002-9297

VL - 85

SP - 745

EP - 749

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

Abstract

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UN SDGs

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