TY - JOUR
T1 - Serious Long-Term Effects of Head and Neck Cancer from the Survivors' Point of View
AU - Taylor, Katherine J
AU - Amdal, Cecilie D
AU - Bjordal, Kristin
AU - Astrup, Guro L
AU - Herlofson, Bente B
AU - Duprez, Fréderic
AU - Gama, Ricardo R
AU - Jacinto, Alexandre
AU - Hammerlid, Eva
AU - Scricciolo, Melissa
AU - Jansen, Femke
AU - Verdonck-de Leeuw, Irma M
AU - Fanetti, Giuseppe
AU - Guntinas-Lichius, Orlando
AU - Inhestern, Johanna
AU - Dragan, Tatiana
AU - Fabian, Alexander
AU - Boehm, Andreas
AU - Wöhner, Ulrike
AU - Kiyota, Naomi
AU - Krüger, Maximilian
AU - Bonomo, Pierluigi
AU - Pinto, Monica
AU - Nuyts, Sandra
AU - Silva, Joaquim C
AU - Stromberger, Carmen
AU - Tramacere, Francesco
AU - Bushnak, Ayman
AU - Perotti, Pietro
AU - Plath, Michaela
AU - Paderno, Alberto
AU - Stempler, Noa
AU - Kouri, Maria
AU - Singer, Susanne
PY - 2023/3/21
Y1 - 2023/3/21
N2 - The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most serious long-term effects. A clinician recorded the responses during face-to-face appointments. A list of 15 example problems was provided, but a free text field was also available. A total of 1033 survivors responded to the question. The most frequent problems were 'dry mouth' (DM) (
n = 476; 46%), 'difficulty swallowing/eating' (DSE) (
n = 408; 40%), 'hoarseness/difficulty speaking' (HDS) (
n = 169; 16%), and 'pain in the head and neck' (PHN) (
n = 142; 14%). A total of 5% reported no problems. Logistic regression adjusted for age, gender, treatment, and tumor stage and site showed increased odds of reporting DM and DSE for chemo-radiotherapy (CRT) alone compared to surgery alone (odds ratio (OR): 4.7, 95% confidence interval (CI): 2.5-9.0; OR: 2.1, CI: 1.1-3.9), but decreased odds for HDS and PHN (OR: 0.3, CI: 0.1-0.6; OR: 0.2, CI: 0.1-0.5). Survivors with UICC stage IV at diagnosis compared to stage I had increased odds of reporting HDS (OR: 1.9, CI: 1.2-3.0). Laryngeal cancer survivors had reduced odds compared to oropharynx cancer survivors of reporting DM (OR: 0.4, CI: 0.3-0.6) but increased odds of HDS (OR: 7.2, CI: 4.3-12.3). This study provides evidence of the serious long-term problems among HNCS.
AB - The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most serious long-term effects. A clinician recorded the responses during face-to-face appointments. A list of 15 example problems was provided, but a free text field was also available. A total of 1033 survivors responded to the question. The most frequent problems were 'dry mouth' (DM) (
n = 476; 46%), 'difficulty swallowing/eating' (DSE) (
n = 408; 40%), 'hoarseness/difficulty speaking' (HDS) (
n = 169; 16%), and 'pain in the head and neck' (PHN) (
n = 142; 14%). A total of 5% reported no problems. Logistic regression adjusted for age, gender, treatment, and tumor stage and site showed increased odds of reporting DM and DSE for chemo-radiotherapy (CRT) alone compared to surgery alone (odds ratio (OR): 4.7, 95% confidence interval (CI): 2.5-9.0; OR: 2.1, CI: 1.1-3.9), but decreased odds for HDS and PHN (OR: 0.3, CI: 0.1-0.6; OR: 0.2, CI: 0.1-0.5). Survivors with UICC stage IV at diagnosis compared to stage I had increased odds of reporting HDS (OR: 1.9, CI: 1.2-3.0). Laryngeal cancer survivors had reduced odds compared to oropharynx cancer survivors of reporting DM (OR: 0.4, CI: 0.3-0.6) but increased odds of HDS (OR: 7.2, CI: 4.3-12.3). This study provides evidence of the serious long-term problems among HNCS.
U2 - 10.3390/healthcare11060906
DO - 10.3390/healthcare11060906
M3 - Article
C2 - 36981562
SN - 2227-9032
VL - 11
JO - Healthcare (Basel)
JF - Healthcare (Basel)
IS - 6
M1 - 906
ER -