Serum albumin and muscle measures in a cohort of healthy young and old participants

E M Reijnierse, M C Trappenburg, M J Leter, S Sipilä, L Stenroth, M V Narici, J Y Hogrel, G Butler-Browne, J S McPhee, M Pääsuke, H Gapeyeva, C G M Meskers, A B Maier

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Consensus on clinically valid diagnostic criteria for sarcopenia requires a systematical assessment of the association of its candidate measures of muscle mass, muscle strength, and physical performance on one side and muscle-related clinical parameters on the other side. In this study, we systematically assessed associations between serum albumin as a muscle-related parameter and muscle measures in 172 healthy young (aged 18-30 years) and 271 old participants (aged 69-81 year) from the European MYOAGE study. Muscle measures included relative muscle mass, i.e., total- and appendicular lean mass (ALM) percentage, absolute muscle mass, i.e., ALM/height(2) and total lean mass in kilograms, handgrip strength, and walking speed. Muscle measures were standardized and analyzed in multivariate linear regression models, stratified by age. Adjustment models included age, body composition, C-reactive protein and lifestyle factors. In young participants, serum albumin was positively associated with lean mass percentage (p = 0.007) and with ALM percentage (p = 0.001). In old participants, serum albumin was not associated with any of the muscle measures. In conclusion, the association between serum albumin and muscle measures was only found in healthy young participants and the strongest for measures of relative muscle mass.

Original languageEnglish
Pages (from-to)88
JournalAge
Volume37
Issue number5
DOIs
Publication statusPublished - Oct 2015

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Serum Albumin
Muscles
Linear Models
Sarcopenia
Social Adjustment
Muscle Strength
Body Composition
C-Reactive Protein
Life Style
Consensus
Healthy Volunteers

Keywords

  • Absorptiometry, Photon
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Body Composition/physiology
  • C-Reactive Protein/metabolism
  • Cross-Sectional Studies
  • Female
  • Humans
  • Life Style
  • Male
  • Muscle Strength/physiology
  • Reference Values
  • Sarcopenia/metabolism
  • Serum Albumin/metabolism
  • Young Adult

Cite this

Reijnierse, E M ; Trappenburg, M C ; Leter, M J ; Sipilä, S ; Stenroth, L ; Narici, M V ; Hogrel, J Y ; Butler-Browne, G ; McPhee, J S ; Pääsuke, M ; Gapeyeva, H ; Meskers, C G M ; Maier, A B. / Serum albumin and muscle measures in a cohort of healthy young and old participants. In: Age. 2015 ; Vol. 37, No. 5. pp. 88.
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abstract = "Consensus on clinically valid diagnostic criteria for sarcopenia requires a systematical assessment of the association of its candidate measures of muscle mass, muscle strength, and physical performance on one side and muscle-related clinical parameters on the other side. In this study, we systematically assessed associations between serum albumin as a muscle-related parameter and muscle measures in 172 healthy young (aged 18-30 years) and 271 old participants (aged 69-81 year) from the European MYOAGE study. Muscle measures included relative muscle mass, i.e., total- and appendicular lean mass (ALM) percentage, absolute muscle mass, i.e., ALM/height(2) and total lean mass in kilograms, handgrip strength, and walking speed. Muscle measures were standardized and analyzed in multivariate linear regression models, stratified by age. Adjustment models included age, body composition, C-reactive protein and lifestyle factors. In young participants, serum albumin was positively associated with lean mass percentage (p = 0.007) and with ALM percentage (p = 0.001). In old participants, serum albumin was not associated with any of the muscle measures. In conclusion, the association between serum albumin and muscle measures was only found in healthy young participants and the strongest for measures of relative muscle mass.",
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year = "2015",
month = "10",
doi = "10.1007/s11357-015-9825-6",
language = "English",
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Reijnierse, EM, Trappenburg, MC, Leter, MJ, Sipilä, S, Stenroth, L, Narici, MV, Hogrel, JY, Butler-Browne, G, McPhee, JS, Pääsuke, M, Gapeyeva, H, Meskers, CGM & Maier, AB 2015, 'Serum albumin and muscle measures in a cohort of healthy young and old participants' Age, vol. 37, no. 5, pp. 88. https://doi.org/10.1007/s11357-015-9825-6

Serum albumin and muscle measures in a cohort of healthy young and old participants. / Reijnierse, E M; Trappenburg, M C; Leter, M J; Sipilä, S; Stenroth, L; Narici, M V; Hogrel, J Y; Butler-Browne, G; McPhee, J S; Pääsuke, M; Gapeyeva, H; Meskers, C G M; Maier, A B.

In: Age, Vol. 37, No. 5, 10.2015, p. 88.

Research output: Contribution to JournalArticleAcademicpeer-review

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T1 - Serum albumin and muscle measures in a cohort of healthy young and old participants

AU - Reijnierse, E M

AU - Trappenburg, M C

AU - Leter, M J

AU - Sipilä, S

AU - Stenroth, L

AU - Narici, M V

AU - Hogrel, J Y

AU - Butler-Browne, G

AU - McPhee, J S

AU - Pääsuke, M

AU - Gapeyeva, H

AU - Meskers, C G M

AU - Maier, A B

PY - 2015/10

Y1 - 2015/10

N2 - Consensus on clinically valid diagnostic criteria for sarcopenia requires a systematical assessment of the association of its candidate measures of muscle mass, muscle strength, and physical performance on one side and muscle-related clinical parameters on the other side. In this study, we systematically assessed associations between serum albumin as a muscle-related parameter and muscle measures in 172 healthy young (aged 18-30 years) and 271 old participants (aged 69-81 year) from the European MYOAGE study. Muscle measures included relative muscle mass, i.e., total- and appendicular lean mass (ALM) percentage, absolute muscle mass, i.e., ALM/height(2) and total lean mass in kilograms, handgrip strength, and walking speed. Muscle measures were standardized and analyzed in multivariate linear regression models, stratified by age. Adjustment models included age, body composition, C-reactive protein and lifestyle factors. In young participants, serum albumin was positively associated with lean mass percentage (p = 0.007) and with ALM percentage (p = 0.001). In old participants, serum albumin was not associated with any of the muscle measures. In conclusion, the association between serum albumin and muscle measures was only found in healthy young participants and the strongest for measures of relative muscle mass.

AB - Consensus on clinically valid diagnostic criteria for sarcopenia requires a systematical assessment of the association of its candidate measures of muscle mass, muscle strength, and physical performance on one side and muscle-related clinical parameters on the other side. In this study, we systematically assessed associations between serum albumin as a muscle-related parameter and muscle measures in 172 healthy young (aged 18-30 years) and 271 old participants (aged 69-81 year) from the European MYOAGE study. Muscle measures included relative muscle mass, i.e., total- and appendicular lean mass (ALM) percentage, absolute muscle mass, i.e., ALM/height(2) and total lean mass in kilograms, handgrip strength, and walking speed. Muscle measures were standardized and analyzed in multivariate linear regression models, stratified by age. Adjustment models included age, body composition, C-reactive protein and lifestyle factors. In young participants, serum albumin was positively associated with lean mass percentage (p = 0.007) and with ALM percentage (p = 0.001). In old participants, serum albumin was not associated with any of the muscle measures. In conclusion, the association between serum albumin and muscle measures was only found in healthy young participants and the strongest for measures of relative muscle mass.

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KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Body Composition/physiology

KW - C-Reactive Protein/metabolism

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Life Style

KW - Male

KW - Muscle Strength/physiology

KW - Reference Values

KW - Sarcopenia/metabolism

KW - Serum Albumin/metabolism

KW - Young Adult

U2 - 10.1007/s11357-015-9825-6

DO - 10.1007/s11357-015-9825-6

M3 - Article

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SP - 88

JO - Age

JF - Age

SN - 0161-9152

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ER -