Serum inflammatory proteins and cognitive decline in older persons

M.G. Dik; C. Jonker; C.E. Hack; J.H. Smit; H.C. Comijs; P. Eikelenboom

doi:10.1212/01.WNL.0000158281.08946.68

Serum inflammatory proteins and cognitive decline in older persons

M.G. Dik, C. Jonker, C.E. Hack, J.H. Smit, H.C. Comijs, P. Eikelenboom

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective: To assess whether serum levels of the inflammatory proteins α1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons.

Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven’s Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up.

Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study.

Conclusions: This population-based study showed that the serum inflammatory protein α1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.

Original language	English
Pages (from-to)	1371-1377
Number of pages	7
Journal	Neurology
Volume	64
Issue number	8
DOIs	https://doi.org/10.1212/01.WNL.0000158281.08946.68
Publication status	Published - 26 Apr 2005

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Working title: The assosiation between inflammatory proteins and cognitive decline in older persons

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title = "Serum inflammatory proteins and cognitive decline in older persons",

abstract = "Objective: To assess whether serum levels of the inflammatory proteins α1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons.Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven{\textquoteright}s Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up.Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study.Conclusions: This population-based study showed that the serum inflammatory protein α1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.",

author = "M.G. Dik and C. Jonker and C.E. Hack and J.H. Smit and H.C. Comijs and P. Eikelenboom",

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AU - Jonker, C.

AU - Hack, C.E.

AU - Smit, J.H.

AU - Comijs, H.C.

AU - Eikelenboom, P.

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PY - 2005/4/26

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N2 - Objective: To assess whether serum levels of the inflammatory proteins α1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons.Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven’s Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up.Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study.Conclusions: This population-based study showed that the serum inflammatory protein α1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.

AB - Objective: To assess whether serum levels of the inflammatory proteins α1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons.Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven’s Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up.Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study.Conclusions: This population-based study showed that the serum inflammatory protein α1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.

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JO - Neurology

JF - Neurology

IS - 8

ER -

Serum inflammatory proteins and cognitive decline in older persons

Abstract

Bibliographical note

UN SDGs

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