Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study

O.J.G. Schiepers; M.P. van Boxtel; R.H.M. de Groot; J. Jolles; W.L. de Kort; D.W. Swinkels; F.J. Kok; P. Verhoef; J. Durga

doi:10.1093/gerona/glq149

Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study

O.J.G. Schiepers, M.P. van Boxtel, R.H.M. de Groot, J. Jolles, W.L. de Kort, D.W. Swinkels, F.J. Kok, P. Verhoef, J. Durga

Clinical Child and Family Studies

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Although iron homeostasis is essential for brain functioning, the effects of iron levels on cognitive performance in older individuals have scarcely been investigated. In the present study, serum iron parameters and hemochromatosis (HFE) C282Y genotype were determined in 818 older individuals who participated in a 3-year randomized, placebo-controlled double-blind trial examining the effects of folic acid on carotid intima-media thickness. All participants had slightly elevated homocysteine levels and were vitamin B12 replete. Cognitive functioning was assessed at baseline and after 3 years by means of a neuropsychological test battery. At baseline, increased serum ferritin was associated with decreased sensorimotor speed, complex speed, and information-processing speed and increased serum iron was associated with decreased sensorimotor speed. Cognitive performance over 3 years was not associated with HFE C282Y genotype or iron parameters. In conclusion, serum iron parameters do not show a straightforward relationship with cognitive functioning, although elevated iron levels may decrease cognitive speed in older individuals susceptible to cognitive impairment. © The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

Original language	English
Pages (from-to)	1312-1321
Number of pages	10
Journal	Journals of Gerontology. Series A : Biological Sciences & Medical Sciences
Volume	65A
Issue number	12
DOIs	https://doi.org/10.1093/gerona/glq149
Publication status	Published - 2010

Access to Document

10.1093/gerona/glq149

Persistent URL (handle)

Copy link address

Cite this

Schiepers, O. J. G., van Boxtel, M. P., de Groot, R. H. M., Jolles, J., de Kort, W. L., Swinkels, D. W., Kok, F. J., Verhoef, P., & Durga, J. (2010). Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study. Journals of Gerontology. Series A : Biological Sciences & Medical Sciences, 65A(12), 1312-1321. https://doi.org/10.1093/gerona/glq149

@article{e5f814fd71b34ac5b5eccfceff65f5ad,

title = "Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study",

abstract = "Although iron homeostasis is essential for brain functioning, the effects of iron levels on cognitive performance in older individuals have scarcely been investigated. In the present study, serum iron parameters and hemochromatosis (HFE) C282Y genotype were determined in 818 older individuals who participated in a 3-year randomized, placebo-controlled double-blind trial examining the effects of folic acid on carotid intima-media thickness. All participants had slightly elevated homocysteine levels and were vitamin B12 replete. Cognitive functioning was assessed at baseline and after 3 years by means of a neuropsychological test battery. At baseline, increased serum ferritin was associated with decreased sensorimotor speed, complex speed, and information-processing speed and increased serum iron was associated with decreased sensorimotor speed. Cognitive performance over 3 years was not associated with HFE C282Y genotype or iron parameters. In conclusion, serum iron parameters do not show a straightforward relationship with cognitive functioning, although elevated iron levels may decrease cognitive speed in older individuals susceptible to cognitive impairment. {\textcopyright} The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.",

author = "O.J.G. Schiepers and {van Boxtel}, M.P. and {de Groot}, R.H.M. and J. Jolles and {de Kort}, W.L. and D.W. Swinkels and F.J. Kok and P. Verhoef and J. Durga",

year = "2010",

doi = "10.1093/gerona/glq149",

language = "English",

volume = "65A",

pages = "1312--1321",

journal = "Journals of Gerontology. Series A : Biological Sciences & Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "12",

}

Schiepers, OJG, van Boxtel, MP, de Groot, RHM, Jolles, J, de Kort, WL, Swinkels, DW, Kok, FJ, Verhoef, P & Durga, J 2010, 'Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study', Journals of Gerontology. Series A : Biological Sciences & Medical Sciences, vol. 65A, no. 12, pp. 1312-1321. https://doi.org/10.1093/gerona/glq149

Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study. / Schiepers, O.J.G.; van Boxtel, M.P.; de Groot, R.H.M. et al.
In: Journals of Gerontology. Series A : Biological Sciences & Medical Sciences, Vol. 65A, No. 12, 2010, p. 1312-1321.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study

AU - Schiepers, O.J.G.

AU - van Boxtel, M.P.

AU - de Groot, R.H.M.

AU - Jolles, J.

AU - de Kort, W.L.

AU - Swinkels, D.W.

AU - Kok, F.J.

AU - Verhoef, P.

AU - Durga, J.

PY - 2010

Y1 - 2010

N2 - Although iron homeostasis is essential for brain functioning, the effects of iron levels on cognitive performance in older individuals have scarcely been investigated. In the present study, serum iron parameters and hemochromatosis (HFE) C282Y genotype were determined in 818 older individuals who participated in a 3-year randomized, placebo-controlled double-blind trial examining the effects of folic acid on carotid intima-media thickness. All participants had slightly elevated homocysteine levels and were vitamin B12 replete. Cognitive functioning was assessed at baseline and after 3 years by means of a neuropsychological test battery. At baseline, increased serum ferritin was associated with decreased sensorimotor speed, complex speed, and information-processing speed and increased serum iron was associated with decreased sensorimotor speed. Cognitive performance over 3 years was not associated with HFE C282Y genotype or iron parameters. In conclusion, serum iron parameters do not show a straightforward relationship with cognitive functioning, although elevated iron levels may decrease cognitive speed in older individuals susceptible to cognitive impairment. © The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

AB - Although iron homeostasis is essential for brain functioning, the effects of iron levels on cognitive performance in older individuals have scarcely been investigated. In the present study, serum iron parameters and hemochromatosis (HFE) C282Y genotype were determined in 818 older individuals who participated in a 3-year randomized, placebo-controlled double-blind trial examining the effects of folic acid on carotid intima-media thickness. All participants had slightly elevated homocysteine levels and were vitamin B12 replete. Cognitive functioning was assessed at baseline and after 3 years by means of a neuropsychological test battery. At baseline, increased serum ferritin was associated with decreased sensorimotor speed, complex speed, and information-processing speed and increased serum iron was associated with decreased sensorimotor speed. Cognitive performance over 3 years was not associated with HFE C282Y genotype or iron parameters. In conclusion, serum iron parameters do not show a straightforward relationship with cognitive functioning, although elevated iron levels may decrease cognitive speed in older individuals susceptible to cognitive impairment. © The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

U2 - 10.1093/gerona/glq149

DO - 10.1093/gerona/glq149

M3 - Article

SN - 1079-5006

VL - 65A

SP - 1312

EP - 1321

JO - Journals of Gerontology. Series A : Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A : Biological Sciences & Medical Sciences

IS - 12

ER -

Serum Iron Parameters, HFE C282Y Genotype, and Cognitive Performance in Older Adults: Results from the FACIT Study

Abstract

Access to Document

Persistent URL (handle)

Fingerprint

Cite this