Seventy-five genetic loci influencing the human red blood cell

P. van der Harst, W. Zhang, I. Mateo Leach, A. Rendon, N. Verweij, J. Sehmi, D.S. Paul, U. Elling, H. Allayee, X. Li, A. Radhakrishnan, S.T. Tan, K. Voss, C.X. Weichenberger, C.A. Albers, A. Al-Hussani, F.W. Asselbergs, M. Ciullo, F. Danjou, C. DinaT. Esko, D.M. Evans, L Franke, M. Gögele, J. Hartiala, M. Hersch, H. Holm, J.J. Hottenga, S. Kanoni, M.E. Kleber, V. Lagou, C. Langenberg, L.M. Lopez, L.P. Lyytikäinen, O. Melander, F. Murgia, I.M. Nolte, P.F. O'Reilly, S. Padmanabhan, A. Parsa, N. Pirastu, E. Porcu, L. Portas, I. Prokopenko, J.S. Ried, S.Y. Shin, C.S. Tang, A. Teumer, M. Traglia, S. Ulivi, H.J. Westra, J. Yang, J.H. Zhao, F. Anni, A. Abdellaoui, A. Attwood, B. Balkau, S. Bandinelli, F. Bastardot, B. Benyamin, B.O. Boehm, W.O. Cookson, D. Das, P.I. de Bakker, R.A. de Boer, E.J.C. de Geus, M.H.M. de Moor, M. Dimitriou, F.S. Domingues, A. Döring, G. Engström, G.I. Eyjolfsson, L. Ferrucci, K. Fischer, R. Galanello, S.F. Garner, B. Genser, Q.D. Gibson, G. Girotto, D.F. Gudbjartsson, S.E. Harris, A.L. Hartikainen, C.E. Hastie, B. Hedblad, T. Illig, J. Jolley, M. Kähönen, I.P. Kema, J.P. Kemp, L. Liang, H. Lloyd-Jones, R.J. Loos, S. Meacham, S.E. Medland, C. Meisinger, Y. Memari, E. Mihailov, K. Miller, M.F. Moffatt, M. Nauck, M. Novatchkova, T. Nutile, I. Olafsson, P.T. Onundarson, D. Parracciani, B.W.J.H. Penninx, L. Perseu, A. Piga, G. Pisits, A. Pouta, U. Puc, O. Raitakari, S.M. Ring, A. Robino, D. Ruggiero, A. Ruokonen, A. Saint-Pierre, C. Sala, A. Salumets, J. Sambrook, H. Schepers, C.O. Schmidt, H.H. Silljé, R. Sladek, J.H. Smit, J.M. Starr, J. Stephens, P. Sulem, T. Tanaka, U. Thorsteinsdottir, V. Tragante, W.H. van Gilst, L.J. van Pelt, D.J. van Veldhuisen, U. Völker, J.B. Whitfield, G. Willemsen, B.R. Winkelmann, G. Wirnsberger, A. Algra, F. Cucca, A.P. d'Adamo, J. Danesh, I.J. Deary, A.F. Dominiczak, P. Elliott, P. Fortina, P. Froguel, P. Gasparini, A. Greinacher, S.L. Hazen, M.-R. Jarvelin, K.T. Khaw, T. Lehtimäki, W. Maerz, N.G. Martin, A. Metspalu, B.D. Mitchell, G.W. Montgomery, C. Moore, G. Navis, M. Pirastu, P.P. Pramstaller, R. Ramirez-Solis, E. Schadt, J. Scott, A.R. Shuldiner, G.D. Smith, J.G. Smith, H. Snieder, R. Sorice, T.D. Spector, K. Stefansson, M. Stumvoll, W.H. Tang, D. Toniolo, A. Tönjes, P.M. Visscher, P. Vollenweider, N.J. Wareham, B.H.R. Wolffenbuttel, D.I. Boomsma, J.S. Beckmann, G.V. Dedoussis, P. Deloukas, M.A. Ferreira, S. Sanna, M. Uda, A.A. Hicks, J.M. Penninger, C. Gieger, J.S. Kooner, W.H. Ouwehand, N. Soranzo, J.C. Chambers

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Abstract

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10
Original languageEnglish
Pages (from-to)369-375
JournalNature
Volume492
Issue number7429
DOIs
Publication statusPublished - 2012

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van der Harst, P., Zhang, W., Mateo Leach, I., Rendon, A., Verweij, N., Sehmi, J., ... Chambers, J. C. (2012). Seventy-five genetic loci influencing the human red blood cell. Nature, 492(7429), 369-375. https://doi.org/10.1038/nature11677