Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure

S.F. Acevedo; I.J.P. de Esch; J. Raber

doi:10.1038/sj.npp.1301091

Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure

S.F. Acevedo, I.J.P. de Esch, J. Raber

Medicinal chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

As prenatal methamphetamine (MA) exposure results in long-term hippocampus-dependent cognitive deficits, the increased MA use in women of childbearing age is of great concern. As mice are most commonly used in genetic models, we started to study the potential effects of neonatal MA exposure in female and male mice on brain function 3 months later. As histamine (HA) might mediate some effects of MA in adulthood, we also tested whether in neonates HA might mediate the long-term effects of MA using HA H

Original language	English
Pages (from-to)	665-72
Journal	Neuropsychopharmacology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1038/sj.npp.1301091
Publication status	Published - 2007

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title = "Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure",

abstract = "As prenatal methamphetamine (MA) exposure results in long-term hippocampus-dependent cognitive deficits, the increased MA use in women of childbearing age is of great concern. As mice are most commonly used in genetic models, we started to study the potential effects of neonatal MA exposure in female and male mice on brain function 3 months later. As histamine (HA) might mediate some effects of MA in adulthood, we also tested whether in neonates HA might mediate the long-term effects of MA using HA H",

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AU - Raber, J.

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AB - As prenatal methamphetamine (MA) exposure results in long-term hippocampus-dependent cognitive deficits, the increased MA use in women of childbearing age is of great concern. As mice are most commonly used in genetic models, we started to study the potential effects of neonatal MA exposure in female and male mice on brain function 3 months later. As histamine (HA) might mediate some effects of MA in adulthood, we also tested whether in neonates HA might mediate the long-term effects of MA using HA H

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DO - 10.1038/sj.npp.1301091

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JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

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Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure

Abstract

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