Shaping of a conformationally flexible molecular structure for spectroscopy

Anouk M. Rijs, Bridgit O. Crews, Mattanjah S. De Vries, Jeffrey S. Hannam, David A. Leigh, Marianna Fanti, Francesco Zerbetto, Wybren J. Buma

Research output: Contribution to JournalArticleAcademicpeer-review


(Chemical Equation Presented) Chaperones for wild molecules: A molecule's conformational flexibility can be eliminated by enclosing it with a macrocyclic mold as a [2]rotaxane (see picture) that forces it into a specific shape. After rapid cooling, the mold is removed with a laser pulse. Through this process, the molded molecule becomes a suitable candidate for high-resolution electronic excitation spectroscopy.

Original languageEnglish
Pages (from-to)3174-3179
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number17
Publication statusPublished - 14 Apr 2008
Externally publishedYes


  • Conformational flexibility
  • Laser spectroscopy
  • Molecular devices
  • Molecular modeling
  • Rotaxanes


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