Abstract
Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.
| Original language | English |
|---|---|
| Pages (from-to) | 1014-1026 |
| Number of pages | 16 |
| Journal | Nature Human Behaviour |
| Volume | 6 |
| Issue number | 7 |
| Early online date | 19 May 2022 |
| DOIs | |
| Publication status | Published - Jul 2022 |
Bibliographical note
Funding Information:KBA genotype data were provided by the Collaborative Genome Program for Fostering New Post-Genome Industry (3000–3031b), and UKB data were obtained under application no. 33002. This study was supported by the National Research Foundation of Korea Grant funded by the Ministry of Science and Information and Communication Technologies, South Korea (grant no. NRF‐2018R1C1B6001708 and NRF-2021R1A2C4001779 to W.M. and NRF-2019R1A2C4070496 and NRF-2022R1A2C2009998 to H.H.W.) and by an intramural grant from the Korea National Institute of Health (2019-NG-053-01). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant nos. HI19C1132 and HI19C1328000020 to H.H.W. and S.K., respectively). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
Funding
KBA genotype data were provided by the Collaborative Genome Program for Fostering New Post-Genome Industry (3000–3031b), and UKB data were obtained under application no. 33002. This study was supported by the National Research Foundation of Korea Grant funded by the Ministry of Science and Information and Communication Technologies, South Korea (grant no. NRF‐2018R1C1B6001708 and NRF-2021R1A2C4001779 to W.M. and NRF-2019R1A2C4070496 and NRF-2022R1A2C2009998 to H.H.W.) and by an intramural grant from the Korea National Institute of Health (2019-NG-053-01). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant nos. HI19C1132 and HI19C1328000020 to H.H.W. and S.K., respectively). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.