Abstract
Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain's connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a 'cross-disorder disconnectivity involvement map' describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.
Original language | English |
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Pages (from-to) | 988-998 |
Number of pages | 11 |
Journal | Nature Human Behaviour |
Volume | 3 |
Issue number | 9 |
Early online date | 5 Aug 2019 |
DOIs | |
Publication status | Published - Sept 2019 |
Funding
L.H.v.d.B. serves on scientific advisory boards for Orion, Biogen and Cytokinetics; received an educational grant from Baxalta; serves on the editorial boards of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration and the Journal of Neurology, Neurosurgery, and Psychiatry; and receives research support from the Prinses Beatrix Spierfonds, the Netherlands ALS Foundation, The European Community’s Health Seventh Framework Programme (grant agreement no. 259867) and The Netherlands Organization for Health Research and Development (Vici Scheme, JPND (SOPHIA, STRENGTH, ALSCare)). All other authors declare no competing interests.
Funders | Funder number |
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European Community’s Health Seventh Framework Programme | 259867 |
National Institute on Aging | U01AG024904 |
EU Joint Programme – Neurodegenerative Disease Research | |
ZonMw | |
Prinses Beatrix Spierfonds | |
Stichting ALS Nederland |