Shifts in growth strategies reflect tradeoffs in cellular economics.

D. Molenaar, R. van Berlo, D. de Ridder, B. Teusink

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    The growth rate-dependent regulation of cell size, ribosomal content, and metabolic efficiency follows a common pattern in unicellular organisms: with increasing growth rates, cell size and ribosomal content increase and a shift to energetically inefficient metabolism takes place. The latter two phenomena are also observed in fast growing tumour cells and cell lines. These patterns suggest a fundamental principle of design. In biology such designs can often be understood as the result of the optimization of fitness. Here we show that in basic models of self-replicating systems these patterns are the consequence of maximizing the growth rate. Whereas most models of cellular growth consider a part of physiology, for instance only metabolism, the approach presented here integrates several subsystems to a complete self-replicating system. Such models can yield fundamentally different optimal strategies. In particular, it is shown how the shift in metabolic efficiency originates from a tradeoff between investments in enzyme synthesis and metabolic yields for alternative catabolic pathways. The models elucidate how the optimization of growth by natural selection shapes growth strategies. © 2009 EMBO and Macmillan Publishers Limited.
    Original languageEnglish
    Pages (from-to)1-10
    JournalMolecular Systems Biology
    Volume5
    Issue numbere-323
    DOIs
    Publication statusPublished - 2009

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