Short communication: Genetic association between schizophrenia and cannabis use

C.J.H. Verweij, A. Abdellaoui, Michel G Nivard, Alberto Sainz Cort, R.S.L. Ligthart, Harmen H M Draisma, C.C. Minica, International Cannabis Consortium, Gonneke Willemsen, J.J. Hottenga, D.I. Boomsma, J.M. Vink

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND AND AIM: Previous studies have shown a relationship between schizophrenia and cannabis use. As both traits are substantially heritable, a shared genetic liability could explain the association. We use two recently developed genomics methods to investigate the genetic overlap between schizophrenia and cannabis use.

METHODS: Firstly, polygenic risk scores for schizophrenia were created based on summary statistics from the largest schizophrenia genome-wide association (GWA) meta-analysis to date. We analysed the association between these schizophrenia polygenic scores and multiple cannabis use phenotypes (lifetime use, regular use, age at initiation, and quantity and frequency of use) in a sample of 6,931 individuals. Secondly, we applied LD-score regression to the GWA summary statistics of schizophrenia and lifetime cannabis use to calculate the genome-wide genetic correlation.

RESULTS: Polygenic risk scores for schizophrenia were significantly (α<0.05) associated with five of the eight cannabis use phenotypes, including lifetime use, regular use, and quantity of use, with risk scores explaining up to 0.5% of the variance. Associations were not significant for age at initiation of use and two measures of frequency of use analyzed in lifetime users only, potentially because of reduced power due to a smaller sample size. The LD-score regression revealed a significant genetic correlation of rg=0.22 (SE=0.07, p=0.003) between schizophrenia and lifetime cannabis use.

CONCLUSIONS: Common genetic variants underlying schizophrenia and lifetime cannabis use are partly overlapping. Individuals with a stronger genetic predisposition to schizophrenia are more likely to initiate cannabis use, use cannabis more regularly, and consume more cannabis over their lifetime.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalDrug and Alcohol Dependence
Volume171
DOIs
Publication statusPublished - 1 Feb 2017

Fingerprint

Cannabis
Schizophrenia
Communication
Genes
Statistics
Genome
Phenotype
Genome-Wide Association Study
Genetic Predisposition to Disease
Genomics
Sample Size
Meta-Analysis

Keywords

  • Journal Article

Cite this

Verweij, C.J.H. ; Abdellaoui, A. ; Nivard, Michel G ; Sainz Cort, Alberto ; Ligthart, R.S.L. ; Draisma, Harmen H M ; Minica, C.C. ; International Cannabis Consortium ; Willemsen, Gonneke ; Hottenga, J.J. ; Boomsma, D.I. ; Vink, J.M. / Short communication : Genetic association between schizophrenia and cannabis use. In: Drug and Alcohol Dependence. 2017 ; Vol. 171. pp. 117-121.
@article{679969ca9c4c425b856c22935f60977a,
title = "Short communication: Genetic association between schizophrenia and cannabis use",
abstract = "BACKGROUND AND AIM: Previous studies have shown a relationship between schizophrenia and cannabis use. As both traits are substantially heritable, a shared genetic liability could explain the association. We use two recently developed genomics methods to investigate the genetic overlap between schizophrenia and cannabis use.METHODS: Firstly, polygenic risk scores for schizophrenia were created based on summary statistics from the largest schizophrenia genome-wide association (GWA) meta-analysis to date. We analysed the association between these schizophrenia polygenic scores and multiple cannabis use phenotypes (lifetime use, regular use, age at initiation, and quantity and frequency of use) in a sample of 6,931 individuals. Secondly, we applied LD-score regression to the GWA summary statistics of schizophrenia and lifetime cannabis use to calculate the genome-wide genetic correlation.RESULTS: Polygenic risk scores for schizophrenia were significantly (α<0.05) associated with five of the eight cannabis use phenotypes, including lifetime use, regular use, and quantity of use, with risk scores explaining up to 0.5{\%} of the variance. Associations were not significant for age at initiation of use and two measures of frequency of use analyzed in lifetime users only, potentially because of reduced power due to a smaller sample size. The LD-score regression revealed a significant genetic correlation of rg=0.22 (SE=0.07, p=0.003) between schizophrenia and lifetime cannabis use.CONCLUSIONS: Common genetic variants underlying schizophrenia and lifetime cannabis use are partly overlapping. Individuals with a stronger genetic predisposition to schizophrenia are more likely to initiate cannabis use, use cannabis more regularly, and consume more cannabis over their lifetime.",
keywords = "Journal Article",
author = "C.J.H. Verweij and A. Abdellaoui and Nivard, {Michel G} and {Sainz Cort}, Alberto and R.S.L. Ligthart and Draisma, {Harmen H M} and C.C. Minica and {International Cannabis Consortium} and Gonneke Willemsen and J.J. Hottenga and D.I. Boomsma and J.M. Vink",
note = "Copyright {\circledC} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.drugalcdep.2016.09.022",
language = "English",
volume = "171",
pages = "117--121",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",

}

Short communication : Genetic association between schizophrenia and cannabis use. / Verweij, C.J.H.; Abdellaoui, A.; Nivard, Michel G; Sainz Cort, Alberto; Ligthart, R.S.L.; Draisma, Harmen H M; Minica, C.C.; International Cannabis Consortium ; Willemsen, Gonneke; Hottenga, J.J.; Boomsma, D.I.; Vink, J.M.

In: Drug and Alcohol Dependence, Vol. 171, 01.02.2017, p. 117-121.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Short communication

T2 - Genetic association between schizophrenia and cannabis use

AU - Verweij, C.J.H.

AU - Abdellaoui, A.

AU - Nivard, Michel G

AU - Sainz Cort, Alberto

AU - Ligthart, R.S.L.

AU - Draisma, Harmen H M

AU - Minica, C.C.

AU - International Cannabis Consortium

AU - Willemsen, Gonneke

AU - Hottenga, J.J.

AU - Boomsma, D.I.

AU - Vink, J.M.

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - BACKGROUND AND AIM: Previous studies have shown a relationship between schizophrenia and cannabis use. As both traits are substantially heritable, a shared genetic liability could explain the association. We use two recently developed genomics methods to investigate the genetic overlap between schizophrenia and cannabis use.METHODS: Firstly, polygenic risk scores for schizophrenia were created based on summary statistics from the largest schizophrenia genome-wide association (GWA) meta-analysis to date. We analysed the association between these schizophrenia polygenic scores and multiple cannabis use phenotypes (lifetime use, regular use, age at initiation, and quantity and frequency of use) in a sample of 6,931 individuals. Secondly, we applied LD-score regression to the GWA summary statistics of schizophrenia and lifetime cannabis use to calculate the genome-wide genetic correlation.RESULTS: Polygenic risk scores for schizophrenia were significantly (α<0.05) associated with five of the eight cannabis use phenotypes, including lifetime use, regular use, and quantity of use, with risk scores explaining up to 0.5% of the variance. Associations were not significant for age at initiation of use and two measures of frequency of use analyzed in lifetime users only, potentially because of reduced power due to a smaller sample size. The LD-score regression revealed a significant genetic correlation of rg=0.22 (SE=0.07, p=0.003) between schizophrenia and lifetime cannabis use.CONCLUSIONS: Common genetic variants underlying schizophrenia and lifetime cannabis use are partly overlapping. Individuals with a stronger genetic predisposition to schizophrenia are more likely to initiate cannabis use, use cannabis more regularly, and consume more cannabis over their lifetime.

AB - BACKGROUND AND AIM: Previous studies have shown a relationship between schizophrenia and cannabis use. As both traits are substantially heritable, a shared genetic liability could explain the association. We use two recently developed genomics methods to investigate the genetic overlap between schizophrenia and cannabis use.METHODS: Firstly, polygenic risk scores for schizophrenia were created based on summary statistics from the largest schizophrenia genome-wide association (GWA) meta-analysis to date. We analysed the association between these schizophrenia polygenic scores and multiple cannabis use phenotypes (lifetime use, regular use, age at initiation, and quantity and frequency of use) in a sample of 6,931 individuals. Secondly, we applied LD-score regression to the GWA summary statistics of schizophrenia and lifetime cannabis use to calculate the genome-wide genetic correlation.RESULTS: Polygenic risk scores for schizophrenia were significantly (α<0.05) associated with five of the eight cannabis use phenotypes, including lifetime use, regular use, and quantity of use, with risk scores explaining up to 0.5% of the variance. Associations were not significant for age at initiation of use and two measures of frequency of use analyzed in lifetime users only, potentially because of reduced power due to a smaller sample size. The LD-score regression revealed a significant genetic correlation of rg=0.22 (SE=0.07, p=0.003) between schizophrenia and lifetime cannabis use.CONCLUSIONS: Common genetic variants underlying schizophrenia and lifetime cannabis use are partly overlapping. Individuals with a stronger genetic predisposition to schizophrenia are more likely to initiate cannabis use, use cannabis more regularly, and consume more cannabis over their lifetime.

KW - Journal Article

U2 - 10.1016/j.drugalcdep.2016.09.022

DO - 10.1016/j.drugalcdep.2016.09.022

M3 - Article

VL - 171

SP - 117

EP - 121

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -