Short communication: Genetic association between schizophrenia and cannabis use

C.J.H. Verweij, A. Abdellaoui, Michel G Nivard, Alberto Sainz Cort, L. Ligthart, Harmen H M Draisma, C.C. Minica, International Cannabis Consortium, G. Willemsen, J.J. Hottenga, D.I. Boomsma, J.M. Vink

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BACKGROUND AND AIM: Previous studies have shown a relationship between schizophrenia and cannabis use. As both traits are substantially heritable, a shared genetic liability could explain the association. We use two recently developed genomics methods to investigate the genetic overlap between schizophrenia and cannabis use.

METHODS: Firstly, polygenic risk scores for schizophrenia were created based on summary statistics from the largest schizophrenia genome-wide association (GWA) meta-analysis to date. We analysed the association between these schizophrenia polygenic scores and multiple cannabis use phenotypes (lifetime use, regular use, age at initiation, and quantity and frequency of use) in a sample of 6,931 individuals. Secondly, we applied LD-score regression to the GWA summary statistics of schizophrenia and lifetime cannabis use to calculate the genome-wide genetic correlation.

RESULTS: Polygenic risk scores for schizophrenia were significantly (α<0.05) associated with five of the eight cannabis use phenotypes, including lifetime use, regular use, and quantity of use, with risk scores explaining up to 0.5% of the variance. Associations were not significant for age at initiation of use and two measures of frequency of use analyzed in lifetime users only, potentially because of reduced power due to a smaller sample size. The LD-score regression revealed a significant genetic correlation of rg=0.22 (SE=0.07, p=0.003) between schizophrenia and lifetime cannabis use.

CONCLUSIONS: Common genetic variants underlying schizophrenia and lifetime cannabis use are partly overlapping. Individuals with a stronger genetic predisposition to schizophrenia are more likely to initiate cannabis use, use cannabis more regularly, and consume more cannabis over their lifetime.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalDrug and Alcohol Dependence
Early online date10 Jan 2017
Publication statusPublished - 1 Feb 2017


FundersFunder number
National Institute of Mental HealthRC2MH089951


    • Journal Article

    Cohort Studies

    • Netherlands Twin Register (NTR)


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