Short psychodynamic supportive psychotherapy, antidepressants, and their combination in the treatment of major depression: A mega-analysis based on three randomized clinical trials

S.C.M. de Maat, J.J.M. Dekker, R.A. Schoevers, G. van Aalst, C.G. Natijk, M. Hendriksen, S. Kool, J. Peen, R. Van, F. de Jonghe

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The efficacy of Short Psychodynamic Supportive Psychotherapy (SPSP) has not yet been compared with pharmacotherapy. A mega-analysis based on three original Randomized Clinical Trials (RCTs) was performed. Patients with (mild to moderate) major depressive disorder were randomized in (24 weeks) SPSP (n = 97), pharmacotherapy (n = 45), or their combination (n = 171). Efficacy was assessed by the Hamilton Depression Rating Scale (HDRS), Clinical Global Impression of Severity and of Improvement (CGI-S), the Symptom Checklist (SCL; depression subscale) and the Quality of Life Depression Scale (QLDS). Pearson χ
Original languageEnglish
Pages (from-to)565-574
JournalDepression and Anxiety
Volume25
Issue number7
DOIs
Publication statusPublished - 2008

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