The authors report the 2-year results of an uncemented resurfacing shoulder prosthesis in 47 patients with primary glenohumeral osteoarthritis who underwent a cementless humeral resurfacing arthroplasty between 2007 and 2009. Constant scores (corrected for sex and age), shoulder function, visual analog pain scales, Dutch Simple Shoulder Tests, and physical SF-12 scores improved significantly (P<.05) from preoperatively to 2 years postoperatively. Mental SF-12 scores remained the same. Complications included 1 traumatic lesser tuberosity avulsion fracture, 1 intra-articular loose body due to a fractured osteophyte, and 1 subscapularis tendon rupture. No patient required revision surgery for any reason. Cementless humeral resurfacing arthroplasty is a viable treatment option for primary glenohumeral arthritis.