Signal recognition partcle mediated protein targeting in Escherichia coli

Q.A. Valent

    Research output: Contribution to JournalArticleAcademicpeer-review


    The signal recognition particle (SRP) is a conserved ribonucleoprotein complex that binds to targeting sequences in nascent secretory and membrane proteins. The SRP guides these proteins to the cytoplasmic membrane in prokaryotes and the endoplasmic reticulum membrane in eukaryotes via an interaction with its cognate receptor. The E. coli SRP is relatively small and is currently used as a model for fundamental and applied studies on translation-linked protein targeting. In this review recent advances in our understanding of the structure and function of the E. coli SRP and its receptor are discussed. In particular, the interplay between the SRP pathway and other targeting routes, the role of guanine nucleotides in cycling of the SRP and the substrate specificity of the SRP are highlighted.
    Original languageEnglish
    Pages (from-to)17-31
    Number of pages14
    JournalAntonie van Leeuwenhoek
    Publication statusPublished - 2001


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