Abstract
We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelated individuals using genome-wide SNP data. We apply the method to 28 complex traits in the UK Biobank data (N = 126,752) and show that on average, 6% of SNPs have nonzero effects, which in total explain 22% of phenotypic variance. We detect significant (P < 0.05/28) signatures of natural selection in the genetic architecture of 23 traits, including reproductive, cardiovascular, and anthropometric traits, as well as educational attainment. The significant estimates of the relationship between effect size and minor allele frequency in complex traits are consistent with a model of negative (or purifying) selection, as confirmed by forward simulation. We conclude that negative selection acts pervasively on the genetic variants associated with human complex traits.
Original language | English |
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Pages (from-to) | 746-753 |
Number of pages | 8 |
Journal | Nature Genetics |
Volume | 50 |
Issue number | 5 |
Early online date | 16 Apr 2018 |
DOIs | |
Publication status | Published - May 2018 |
Funding
This research was supported by the Australian Research Council (DP160101343, DP160101056, DP160103860, and DP160102400), the Australian National Health and Medical Research Council (1107258, 1078901, 1078037, 1083656, 1078399, 1046880, and 1113400), the US National Institutes of Health (MH100141, GM099568, ES025052, and AG042568), and the Sylvia & Charles Viertel Charitable Foundation (Senior Medical Research Fellowship). R.d.V. acknowledges funding from an ERC consolidator grant (647648 EdGe, awarded to Philipp Koellinger). We thank The University of Queensland’s Research Computing Centre (RCC) for its support in this research. We thank F. Zhang for building the website for the software tool GCTB. This research was supported by the Australian Research Council (DP160101343, DP160101056, DP160103860, and DP160102400), the Australian National Health and Medical Research Council (1107258, 1078901, 1078037, 1083656, 1078399, 1046880, and 1113400), the US National Institutes of Health (MH100141, GM099568, ES025052, and AG042568), and the Sylvia & Charles Viertel Charitable Foundation (Senior Medical Research Fellowship). R.d.V. acknowledges funding from an ERC consolidator grant (647648 EdGe, awarded to Philipp Koellinger). This study makes use of data from dbGaP (accessions: phs000090 and phs000091), UK10K project (EGA accessions: EGAS00001000108 and EGAS00001000090), and UK Biobank Resource (application number: 12514). A full list of acknowledgements for these datasets can be found in part 19 of the Supplementary Note.
Funders | Funder number |
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Australian National Health and Medical Research Council | |
US National Institutes of Health | |
National Institutes of Health | ES025052, GM099568, MH100141, AG042568 |
Sylvia and Charles Viertel Charitable Foundation | |
Horizon 2020 Framework Programme | 692145, 647648 |
European Research Council | |
Australian Research Council | DP160101343, DP160102400, DP160101056, DP160103860 |
National Health and Medical Research Council | 1078901, 1107258, 1078399, 1083656, 1113400, 1046880, 1078037 |