Significance of GABAergic systems in the action of improgan, a non-opioid analgesic

L.H. Hough; J.B. Nalwalk; R. Leurs; W.M.P.B. Menge; H. Timmerman

doi:10.1016/S0024-3205(01)01080-3

Significance of GABAergic systems in the action of improgan, a non-opioid analgesic

L.H. Hough, J.B. Nalwalk, R. Leurs, W.M.P.B. Menge, H. Timmerman

Chemistry and Pharmaceutical Sciences

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Improgan is the prototype drug from a new class of non-opioid analgesics chemically related to histamine and histamine antagonists, but the mechanism of action of these compounds has not been identified. Because several classes of analgesics act in the brain by reducing GABAergic inhibition of endogenous pain-relieving circuits, and because the activity of these substances is abolished by the GABA

Original language	English
Pages (from-to)	2751-7
Journal	Life Sciences
Volume	68
Issue number	24
DOIs	https://doi.org/10.1016/S0024-3205(01)01080-3
Publication status	Published - 2001

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10.1016/S0024-3205(01)01080-3

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title = "Significance of GABAergic systems in the action of improgan, a non-opioid analgesic",

abstract = "Improgan is the prototype drug from a new class of non-opioid analgesics chemically related to histamine and histamine antagonists, but the mechanism of action of these compounds has not been identified. Because several classes of analgesics act in the brain by reducing GABAergic inhibition of endogenous pain-relieving circuits, and because the activity of these substances is abolished by the GABA",

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AU - Leurs, R.

AU - Menge, W.M.P.B.

AU - Timmerman, H.

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AB - Improgan is the prototype drug from a new class of non-opioid analgesics chemically related to histamine and histamine antagonists, but the mechanism of action of these compounds has not been identified. Because several classes of analgesics act in the brain by reducing GABAergic inhibition of endogenous pain-relieving circuits, and because the activity of these substances is abolished by the GABA

U2 - 10.1016/S0024-3205(01)01080-3

DO - 10.1016/S0024-3205(01)01080-3

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JO - Life Sciences

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Significance of GABAergic systems in the action of improgan, a non-opioid analgesic

Abstract

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