Size-selective detection in integrated optical interferometric biosensors

Harmen K P Mulder, Aurel Ymeti, Vinod Subramaniam, Johannes S Kanger

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    We present a new size-selective detection method for integrated optical interferometric biosensors that can strongly enhance their performance. We demonstrate that by launching multiple wavelengths into a Young interferometer waveguide sensor it is feasible to derive refractive index changes from different regions above the waveguide surface, enabling one to distinguish between bound particles (e.g. proteins, viruses, bacteria) based on their differences in size and simultaneously eliminating interference from bulk refractive index changes. Therefore it is anticipated that this new method will be ideally suited for the detection of viruses in complex media. Numerical calculations are used to optimize sensor design and the detection method. Furthermore the specific case of virus detection is analyzed theoretically showing a minimum detectable virus mass coverage of 4 × 10(2) fg/mm(2) < (typically corresponding to 5 × 10(1) particles/ml).

    Original languageEnglish
    Pages (from-to)20934-20950
    Number of pages17
    JournalOptics Express
    Volume20
    Issue number19
    DOIs
    Publication statusPublished - 10 Sep 2012

    Keywords

    • Biosensing Techniques
    • HIV-1
    • Herpesvirus 1, Human
    • Interferometry
    • Optical Phenomena
    • Refractometry
    • Journal Article
    • Research Support, Non-U.S. Gov't

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