Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review

S. Kazem; E.C. Linssen; S. Gibbs

doi:10.1016/j.drudis.2019.06.002

Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review

S. Kazem, E.C. Linssen, S. Gibbs

Oral Cell Biology

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Abstract

Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme activity. Almost all of the xenobiotic metabolizing enzymes detected in human skin are also present in liver. However, in general the relative levels are lower in skin than in liver and fewer enzymes are reported.

Original language	English
Pages (from-to)	1899-1910
Number of pages	12
Journal	Drug Discovery Today
Volume	24
Issue number	9
DOIs	https://doi.org/10.1016/j.drudis.2019.06.002
Publication status	Published - 1 Sept 2019

Funding

This work was supported by the Dutch NWO Domain Applied and Engineering Sciences (AES); TTW NextSkin, project number: 15581.

Funders	Funder number
NWO domain Applied and Engineering Sciences
AES Corporation	15581

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drudis.2019.06.002

https://hdl.handle.net/11245.1/00465e5b-e8b2-45f4-8801-d3a525d00b28

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abstract = "Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme activity. Almost all of the xenobiotic metabolizing enzymes detected in human skin are also present in liver. However, in general the relative levels are lower in skin than in liver and fewer enzymes are reported.",

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AU - Linssen, E.C.

AU - Gibbs, S.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme activity. Almost all of the xenobiotic metabolizing enzymes detected in human skin are also present in liver. However, in general the relative levels are lower in skin than in liver and fewer enzymes are reported.

AB - Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme activity. Almost all of the xenobiotic metabolizing enzymes detected in human skin are also present in liver. However, in general the relative levels are lower in skin than in liver and fewer enzymes are reported.

U2 - 10.1016/j.drudis.2019.06.002

DO - 10.1016/j.drudis.2019.06.002

M3 - Review article

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EP - 1910

JO - Drug Discovery Today

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ER -

Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review

Abstract

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UN SDGs

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