SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis

T.M.H. de Jong; A. Jochens; Y. Jockel-Schneider; I. Harks; H. Dommisch; C. Graetz; F. Flachsbart; I. Staufenbiel; J. Eberhard; M. Folwaczny; B. Noack; J. Meyle; P. Eikholz; C. Gieger; H. Grallert; W. Lieb; A. Franke; A. Nebel; S. Schreiber; C. Doerfer; S. Jepsen; C. Bruckmann; U. van der Velden; B.G. Loos; A.S. Schaefer

doi:10.1111/jcpe.12253

SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis

T.M.H. de Jong
, A. Jochens
, Y. Jockel-Schneider
, I. Harks
, H. Dommisch
, C. Graetz
, F. Flachsbart
, I. Staufenbiel
, J. Eberhard
, M. Folwaczny
, B. Noack
, J. Meyle
, P. Eikholz
, C. Gieger
, H. Grallert
, W. Lieb
, A. Franke
, A. Nebel
, S. Schreiber
, C. Doerfer

S. Jepsen, C. Bruckmann, U. van der Velden, B.G. Loos, A.S. Schaefer

Periodontology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aim
Identification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP).

Material and Methods
Employment of three independent case-control samples of AgP (I. 283 cases, 979 controls; II. 417 cases, 1912 controls; III. 164 cases, 357 controls) and one sample of CP (1359 cases, 1296 controls).

Results
Stage 1: Among the tested single-nucleotide polymorphisms (SNPs), the rare allele (RA) of rs6596473 in SLC23A1 showed nominal significant association with AgP (p = 0.026, odds ratio [OR] 1.26, and a highly similar minor allele frequency between different control panels. Stage 2: rs6596473 showed no significant association with AgP in the replication with the German and Dutch case-control samples. After pooling the German AgP populations (674 cases, 2891 controls) to significantly increase the statistical power (SP = 0.81), rs6596473 RA showed significant association with AgP prior to and upon adjustment with the covariates smoking and gender with padj = 0.005, OR = 1.35. Stage 3: RA of rs6596473 showed no significant association with severe CP.

Conclusion
SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. These results add to previous reports that vitamin C plays a role in the pathogenesis of periodontitis.

Original language	English
Pages (from-to)	531-540
Journal	Journal of Clinical Periodontology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1111/jcpe.12253
Publication status	Published - 2014

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SDG 3 Good Health and Well-being

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de Jong, T. M. H., Jochens, A., Jockel-Schneider, Y., Harks, I., Dommisch, H., Graetz, C., Flachsbart, F., Staufenbiel, I., Eberhard, J., Folwaczny, M., Noack, B., Meyle, J., Eikholz, P., Gieger, C., Grallert, H., Lieb, W., Franke, A., Nebel, A., Schreiber, S., ... Schaefer, A. S. (2014). SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis. Journal of Clinical Periodontology, 41(6), 531-540. https://doi.org/10.1111/jcpe.12253

@article{fa594cce31874dae9521fc3c7f3f5798,

title = "SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis",

abstract = "Aim Identification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP). Material and Methods Employment of three independent case-control samples of AgP (I. 283 cases, 979 controls; II. 417 cases, 1912 controls; III. 164 cases, 357 controls) and one sample of CP (1359 cases, 1296 controls). Results Stage 1: Among the tested single-nucleotide polymorphisms (SNPs), the rare allele (RA) of rs6596473 in SLC23A1 showed nominal significant association with AgP (p = 0.026, odds ratio [OR] 1.26, and a highly similar minor allele frequency between different control panels. Stage 2: rs6596473 showed no significant association with AgP in the replication with the German and Dutch case-control samples. After pooling the German AgP populations (674 cases, 2891 controls) to significantly increase the statistical power (SP = 0.81), rs6596473 RA showed significant association with AgP prior to and upon adjustment with the covariates smoking and gender with padj = 0.005, OR = 1.35. Stage 3: RA of rs6596473 showed no significant association with severe CP. Conclusion SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. These results add to previous reports that vitamin C plays a role in the pathogenesis of periodontitis.",

author = "\{de Jong\}, T.M.H. and A. Jochens and Y. Jockel-Schneider and I. Harks and H. Dommisch and C. Graetz and F. Flachsbart and I. Staufenbiel and J. Eberhard and M. Folwaczny and B. Noack and J. Meyle and P. Eikholz and C. Gieger and H. Grallert and W. Lieb and A. Franke and A. Nebel and S. Schreiber and C. Doerfer and S. Jepsen and C. Bruckmann and \{van der Velden\}, U. and B.G. Loos and A.S. Schaefer",

year = "2014",

doi = "10.1111/jcpe.12253",

language = "English",

volume = "41",

pages = "531--540",

journal = "Journal of Clinical Periodontology",

issn = "0303-6979",

publisher = "Blackwell Munksgaard",

number = "6",

}

de Jong, TMH, Jochens, A, Jockel-Schneider, Y, Harks, I, Dommisch, H, Graetz, C, Flachsbart, F, Staufenbiel, I, Eberhard, J, Folwaczny, M, Noack, B, Meyle, J, Eikholz, P, Gieger, C, Grallert, H, Lieb, W, Franke, A, Nebel, A, Schreiber, S, Doerfer, C, Jepsen, S, Bruckmann, C, van der Velden, U , Loos, BG & Schaefer, AS 2014, 'SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis', Journal of Clinical Periodontology, vol. 41, no. 6, pp. 531-540. https://doi.org/10.1111/jcpe.12253

TY - JOUR

T1 - SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis

AU - de Jong, T.M.H.

AU - Jochens, A.

AU - Jockel-Schneider, Y.

AU - Harks, I.

AU - Dommisch, H.

AU - Graetz, C.

AU - Flachsbart, F.

AU - Staufenbiel, I.

AU - Eberhard, J.

AU - Folwaczny, M.

AU - Noack, B.

AU - Meyle, J.

AU - Eikholz, P.

AU - Gieger, C.

AU - Grallert, H.

AU - Lieb, W.

AU - Franke, A.

AU - Nebel, A.

AU - Schreiber, S.

AU - Doerfer, C.

AU - Jepsen, S.

AU - Bruckmann, C.

AU - van der Velden, U.

AU - Loos, B.G.

AU - Schaefer, A.S.

PY - 2014

Y1 - 2014

N2 - Aim Identification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP). Material and Methods Employment of three independent case-control samples of AgP (I. 283 cases, 979 controls; II. 417 cases, 1912 controls; III. 164 cases, 357 controls) and one sample of CP (1359 cases, 1296 controls). Results Stage 1: Among the tested single-nucleotide polymorphisms (SNPs), the rare allele (RA) of rs6596473 in SLC23A1 showed nominal significant association with AgP (p = 0.026, odds ratio [OR] 1.26, and a highly similar minor allele frequency between different control panels. Stage 2: rs6596473 showed no significant association with AgP in the replication with the German and Dutch case-control samples. After pooling the German AgP populations (674 cases, 2891 controls) to significantly increase the statistical power (SP = 0.81), rs6596473 RA showed significant association with AgP prior to and upon adjustment with the covariates smoking and gender with padj = 0.005, OR = 1.35. Stage 3: RA of rs6596473 showed no significant association with severe CP. Conclusion SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. These results add to previous reports that vitamin C plays a role in the pathogenesis of periodontitis.

AB - Aim Identification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP). Material and Methods Employment of three independent case-control samples of AgP (I. 283 cases, 979 controls; II. 417 cases, 1912 controls; III. 164 cases, 357 controls) and one sample of CP (1359 cases, 1296 controls). Results Stage 1: Among the tested single-nucleotide polymorphisms (SNPs), the rare allele (RA) of rs6596473 in SLC23A1 showed nominal significant association with AgP (p = 0.026, odds ratio [OR] 1.26, and a highly similar minor allele frequency between different control panels. Stage 2: rs6596473 showed no significant association with AgP in the replication with the German and Dutch case-control samples. After pooling the German AgP populations (674 cases, 2891 controls) to significantly increase the statistical power (SP = 0.81), rs6596473 RA showed significant association with AgP prior to and upon adjustment with the covariates smoking and gender with padj = 0.005, OR = 1.35. Stage 3: RA of rs6596473 showed no significant association with severe CP. Conclusion SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. These results add to previous reports that vitamin C plays a role in the pathogenesis of periodontitis.

U2 - 10.1111/jcpe.12253

DO - 10.1111/jcpe.12253

M3 - Article

SN - 0303-6979

VL - 41

SP - 531

EP - 540

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

IS - 6

ER -

SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis

Abstract

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