TY - JOUR
T1 - Sleep disturbances and incident risk of major depressive disorder in a population-based cohort
AU - Solelhac, Geoffroy
AU - Imler, Théo
AU - Strippoli, Marie-Pierre F.
AU - Marchi, Nicola Andrea
AU - Berger, Mathieu
AU - Haba-Rubio, Jose
AU - Raffray, Tifenn
AU - Bayon, Virginie
AU - Lombardi, Anne Sophie
AU - Ranjbar, Setareh
AU - Siclari, Francesca
AU - Vollenweider, Peter
AU - Marques-Vidal, Pedro
AU - Geoffroy, Pierre-Alexis
AU - Léger, Damien
AU - Stephan, Aurélie
AU - Preisig, Martin
AU - Heinzer, Raphaël
PY - 2024/8/1
Y1 - 2024/8/1
N2 - Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years’ follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022–1.103], p = 0.002 and 1.437 [1.064–1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064–1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463–0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.
AB - Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years’ follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022–1.103], p = 0.002 and 1.437 [1.064–1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064–1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463–0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.
UR - http://www.scopus.com/inward/record.url?scp=85194941489&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2024.115934
DO - 10.1016/j.psychres.2024.115934
M3 - Article
SN - 0165-1781
VL - 338
JO - Psychiatry Research
JF - Psychiatry Research
M1 - 115934
ER -