TY - JOUR
T1 - Slowing of M1 activity in Parkinson's disease during rest and movement - An MEG study
AU - Vardy, A.N.
AU - van Wegen, E.E.H.
AU - Kwakkel, G.
AU - Berendse, H.W.
AU - Beek, P.J.
AU - Daffertshofer, A.
PY - 2011
Y1 - 2011
N2 - Objective: Parkinson's disease is characterized by motor and cognitive problems that are accompanied by slowing of neural activity. This study examined the relationship between neural slowing and disease severity during rest and motor performance. Methods: Primary motor activity was assessed by means of magnetoencephalography during rest and rhythmic movements. Motor output and event-related cortical power in the alpha and beta frequency bands were determined. UPDRS total and subscores were used to pinpoint correlates of neural slowing (change of power towards lower frequencies) during both resting state and the production of rhythmic movements. Results: By design, motor performance was similar for both the patients and the controls. PD patients showed slowing of neural activity which increased with disease severity. Slowing during rest showed the clearest correlation with cognitive UPDRS subscores, whereas slowing during movement correlated best with the motor UPDRS subscore. Conclusions: These results suggest that slowing is functionally modulated and that different mechanisms are responsible for neural slowing during rest versus movement. Significance: Neural slowing must be viewed in a broader context than previously thought because it is not solely related to impaired motor performance but also to impaired cognition. © 2010 International Federation of Clinical Neurophysiology.
AB - Objective: Parkinson's disease is characterized by motor and cognitive problems that are accompanied by slowing of neural activity. This study examined the relationship between neural slowing and disease severity during rest and motor performance. Methods: Primary motor activity was assessed by means of magnetoencephalography during rest and rhythmic movements. Motor output and event-related cortical power in the alpha and beta frequency bands were determined. UPDRS total and subscores were used to pinpoint correlates of neural slowing (change of power towards lower frequencies) during both resting state and the production of rhythmic movements. Results: By design, motor performance was similar for both the patients and the controls. PD patients showed slowing of neural activity which increased with disease severity. Slowing during rest showed the clearest correlation with cognitive UPDRS subscores, whereas slowing during movement correlated best with the motor UPDRS subscore. Conclusions: These results suggest that slowing is functionally modulated and that different mechanisms are responsible for neural slowing during rest versus movement. Significance: Neural slowing must be viewed in a broader context than previously thought because it is not solely related to impaired motor performance but also to impaired cognition. © 2010 International Federation of Clinical Neurophysiology.
UR - https://www.scopus.com/pages/publications/79952315599
UR - https://www.scopus.com/inward/citedby.url?scp=79952315599&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2010.10.034
DO - 10.1016/j.clinph.2010.10.034
M3 - Article
SN - 1388-2457
VL - 122
SP - 789
EP - 795
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 4
ER -