Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics

C. de Graaf, H.F. Vischer, G.E. de Kloe, A.J. Kooistra, S. Nijmeijer, M. Kuijer, M.H.P. Verheij, P. England, J.E. van Muijlwijk-Koezen, R. Leurs, I.J.P. de Esch

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Smaller stones with a wide variety of colors make a higher resolution mosaic. In much the same way, smaller chemical entities that are structurally diverse are better able to interrogate protein binding sites. This feature article describes the construction of a diverse fragment library and an analysis of the screening of six representative protein targets belonging to three diverse target classes (G protein-coupled receptors ADRB2, H
Original languageEnglish
Pages (from-to)323-330
JournalDrug Discovery Today
Volume2013
Issue number18
DOIs
Publication statusPublished - 2013

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G-Protein-Coupled Receptors
Protein Binding
Color
Binding Sites
Proteins

Cite this

de Graaf, C. ; Vischer, H.F. ; de Kloe, G.E. ; Kooistra, A.J. ; Nijmeijer, S. ; Kuijer, M. ; Verheij, M.H.P. ; England, P. ; van Muijlwijk-Koezen, J.E. ; Leurs, R. ; de Esch, I.J.P. / Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics. In: Drug Discovery Today. 2013 ; Vol. 2013, No. 18. pp. 323-330.
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abstract = "Smaller stones with a wide variety of colors make a higher resolution mosaic. In much the same way, smaller chemical entities that are structurally diverse are better able to interrogate protein binding sites. This feature article describes the construction of a diverse fragment library and an analysis of the screening of six representative protein targets belonging to three diverse target classes (G protein-coupled receptors ADRB2, H",
author = "{de Graaf}, C. and H.F. Vischer and {de Kloe}, G.E. and A.J. Kooistra and S. Nijmeijer and M. Kuijer and M.H.P. Verheij and P. England and {van Muijlwijk-Koezen}, J.E. and R. Leurs and {de Esch}, I.J.P.",
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de Graaf, C, Vischer, HF, de Kloe, GE, Kooistra, AJ, Nijmeijer, S, Kuijer, M, Verheij, MHP, England, P, van Muijlwijk-Koezen, JE, Leurs, R & de Esch, IJP 2013, 'Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics' Drug Discovery Today, vol. 2013, no. 18, pp. 323-330. https://doi.org/10.1016/j.drudis.2012.12.003

Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics. / de Graaf, C.; Vischer, H.F.; de Kloe, G.E.; Kooistra, A.J.; Nijmeijer, S.; Kuijer, M.; Verheij, M.H.P.; England, P.; van Muijlwijk-Koezen, J.E.; Leurs, R.; de Esch, I.J.P.

In: Drug Discovery Today, Vol. 2013, No. 18, 2013, p. 323-330.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Nijmeijer, S.

AU - Kuijer, M.

AU - Verheij, M.H.P.

AU - England, P.

AU - van Muijlwijk-Koezen, J.E.

AU - Leurs, R.

AU - de Esch, I.J.P.

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