TY - JOUR
T1 - Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics
AU - de Graaf, C.
AU - Vischer, H.F.
AU - de Kloe, G.E.
AU - Kooistra, A.J.
AU - Nijmeijer, S.
AU - Kuijer, M.
AU - Verheij, M.H.P.
AU - England, P.
AU - van Muijlwijk-Koezen, J.E.
AU - Leurs, R.
AU - de Esch, I.J.P.
PY - 2013
Y1 - 2013
N2 - Smaller stones with a wide variety of colors make a higher resolution mosaic. In much the same way, smaller chemical entities that are structurally diverse are better able to interrogate protein binding sites. This feature article describes the construction of a diverse fragment library and an analysis of the screening of six representative protein targets belonging to three diverse target classes (G protein-coupled receptors ADRB2, H
AB - Smaller stones with a wide variety of colors make a higher resolution mosaic. In much the same way, smaller chemical entities that are structurally diverse are better able to interrogate protein binding sites. This feature article describes the construction of a diverse fragment library and an analysis of the screening of six representative protein targets belonging to three diverse target classes (G protein-coupled receptors ADRB2, H
UR - https://www.scopus.com/pages/publications/84875710113
UR - https://www.scopus.com/inward/citedby.url?scp=84875710113&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2012.12.003
DO - 10.1016/j.drudis.2012.12.003
M3 - Article
SN - 1359-6446
VL - 2013
SP - 323
EP - 330
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 18
ER -