Solid-{hase synthesis of 4-substituted Imidazoles Using a scaffold Approach.

E. Gelens, W.J. Koot, W.M.P.B. Menge, H.C.J. Ottenheijm, H. Timmerman

Research output: Contribution to JournalArticleAcademicpeer-review


Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles. (C) 2000 Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)1935-1938
JournalBioorganic and Medicinal Chemistry Letters
Publication statusPublished - 2000


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