Solid-{hase synthesis of 4-substituted Imidazoles Using a scaffold Approach.

E. Gelens; W.J. Koot; W.M.P.B. Menge; H.C.J. Ottenheijm; H. Timmerman

doi:10.1016/S0960-894X(00)00363-2

Solid-{hase synthesis of 4-substituted Imidazoles Using a scaffold Approach.

E. Gelens, W.J. Koot, W.M.P.B. Menge, H.C.J. Ottenheijm, H. Timmerman

Medicinal chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	1935-1938
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
DOIs	https://doi.org/10.1016/S0960-894X(00)00363-2
Publication status	Published - 2000

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title = "Solid-{hase synthesis of 4-substituted Imidazoles Using a scaffold Approach.",

abstract = "Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles. (C) 2000 Elsevier Science Ltd.",

author = "E. Gelens and W.J. Koot and W.M.P.B. Menge and H.C.J. Ottenheijm and H. Timmerman",

year = "2000",

doi = "10.1016/S0960-894X(00)00363-2",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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AU - Gelens, E.

AU - Koot, W.J.

AU - Menge, W.M.P.B.

AU - Ottenheijm, H.C.J.

AU - Timmerman, H.

PY - 2000

Y1 - 2000

N2 - Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles. (C) 2000 Elsevier Science Ltd.

AB - Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles. (C) 2000 Elsevier Science Ltd.

U2 - 10.1016/S0960-894X(00)00363-2

DO - 10.1016/S0960-894X(00)00363-2

M3 - Article

VL - 10

SP - 1935

EP - 1938

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

ER -

Solid-{hase synthesis of 4-substituted Imidazoles Using a scaffold Approach.

Abstract

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