Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

S.H.C. Askes; S. Bonnet

doi:10.1038/s41570-018-0057-z

Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

© 2018, Springer Nature Limited.The conversion of low-energy light into high-energy light, also known as upconversion, can be exploited in life science applications such as bioimaging and phototherapy. Sensitized triplet–triplet annihilation upconversion (sTTA-UC) is one type of upconversion in which a photosensitizer is excited using a low-energy light and then transfers energy to an annihilator that emits at much higher energy. Changing the molecular components enables the fine-tuning of excitation and emission wavelengths. sTTA-UC is an appealing approach because it results in high upconversion efficiencies. However, its sensitivity to the presence of dioxygen in living cells and biological tissues is problematic. In this Review, the essential requirements of sTTA-UC for bio-nanodevices and life science applications are outlined before discussing the different ways to circumvent the dioxygen sensitivity of sTTA-UC.

Original language	English
Pages (from-to)	437-452
Journal	Nature Reviews Chemistry
Volume	2
Issue number	12
DOIs	https://doi.org/10.1038/s41570-018-0057-z
Publication status	Published - 1 Dec 2018
Externally published	Yes

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title = "Solving the oxygen sensitivity of sensitized photon upconversion in life science applications",

abstract = "{\textcopyright} 2018, Springer Nature Limited.The conversion of low-energy light into high-energy light, also known as upconversion, can be exploited in life science applications such as bioimaging and phototherapy. Sensitized triplet–triplet annihilation upconversion (sTTA-UC) is one type of upconversion in which a photosensitizer is excited using a low-energy light and then transfers energy to an annihilator that emits at much higher energy. Changing the molecular components enables the fine-tuning of excitation and emission wavelengths. sTTA-UC is an appealing approach because it results in high upconversion efficiencies. However, its sensitivity to the presence of dioxygen in living cells and biological tissues is problematic. In this Review, the essential requirements of sTTA-UC for bio-nanodevices and life science applications are outlined before discussing the different ways to circumvent the dioxygen sensitivity of sTTA-UC.",

author = "S.H.C. Askes and S. Bonnet",

year = "2018",

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doi = "10.1038/s41570-018-0057-z",

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T1 - Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

AU - Askes, S.H.C.

AU - Bonnet, S.

PY - 2018/12/1

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N2 - © 2018, Springer Nature Limited.The conversion of low-energy light into high-energy light, also known as upconversion, can be exploited in life science applications such as bioimaging and phototherapy. Sensitized triplet–triplet annihilation upconversion (sTTA-UC) is one type of upconversion in which a photosensitizer is excited using a low-energy light and then transfers energy to an annihilator that emits at much higher energy. Changing the molecular components enables the fine-tuning of excitation and emission wavelengths. sTTA-UC is an appealing approach because it results in high upconversion efficiencies. However, its sensitivity to the presence of dioxygen in living cells and biological tissues is problematic. In this Review, the essential requirements of sTTA-UC for bio-nanodevices and life science applications are outlined before discussing the different ways to circumvent the dioxygen sensitivity of sTTA-UC.

AB - © 2018, Springer Nature Limited.The conversion of low-energy light into high-energy light, also known as upconversion, can be exploited in life science applications such as bioimaging and phototherapy. Sensitized triplet–triplet annihilation upconversion (sTTA-UC) is one type of upconversion in which a photosensitizer is excited using a low-energy light and then transfers energy to an annihilator that emits at much higher energy. Changing the molecular components enables the fine-tuning of excitation and emission wavelengths. sTTA-UC is an appealing approach because it results in high upconversion efficiencies. However, its sensitivity to the presence of dioxygen in living cells and biological tissues is problematic. In this Review, the essential requirements of sTTA-UC for bio-nanodevices and life science applications are outlined before discussing the different ways to circumvent the dioxygen sensitivity of sTTA-UC.

U2 - 10.1038/s41570-018-0057-z

DO - 10.1038/s41570-018-0057-z

M3 - Review article

SN - 2397-3358

VL - 2

SP - 437

EP - 452

JO - Nature Reviews Chemistry

JF - Nature Reviews Chemistry

IS - 12

ER -

Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

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