Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

S.H.C. Askes; S. Bonnet

doi:10.1038/s41570-018-0057-z

Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

S.H.C. Askes
, S. Bonnet

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The conversion of low-energy light into high-energy light, also known as upconversion, can be exploited in life science applications such as bioimaging and phototherapy. Sensitized triplet–triplet annihilation upconversion (sTTA-UC) is one type of upconversion in which a photosensitizer is excited using a low-energy light and then transfers energy to an annihilator that emits at much higher energy. Changing the molecular components enables the fine-tuning of excitation and emission wavelengths. sTTA-UC is an appealing approach because it results in high upconversion efficiencies. However, its sensitivity to the presence of dioxygen in living cells and biological tissues is problematic. In this Review, the essential requirements of sTTA-UC for bio-nanodevices and life science applications are outlined before discussing the different ways to circumvent the dioxygen sensitivity of sTTA-UC.

Original language	English
Pages (from-to)	437-452
Number of pages	16
Journal	Nature Reviews. Chemistry
Volume	2
Issue number	12
Early online date	26 Nov 2018
DOIs	https://doi.org/10.1038/s41570-018-0057-z
Publication status	Published - Dec 2018
Externally published	Yes

Bibliographical note

Funding

This work was supported by the Dutch Organization for Scientific Research (NWO-CW) via an Innovational Research Incentives Scheme (VIDI) grant to S.B. The European Research Council is kindly acknowledged for a Starting Grant to S.B. E. Bouwman is gratefully acknowledged for her support and input.

Funders
Dutch Organization for Scientific Research
NWO-CW
European Research Council

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Solving the oxygen sensitivity of sensitized photon upconversion in life science applications

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