Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

M. Lijffijt; P.S. van Dam; J.L. Kenemans; H.P.F. Koppeschaar; W.R. de Vries; M.L. Drent; A. Wittenberg; C. Kemner

doi:10.1016/j.neulet.2003.09.028

Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

M. Lijffijt
, P.S. van Dam
, J.L. Kenemans
, H.P.F. Koppeschaar
, W.R. de Vries
, M.L. Drent
, A. Wittenberg
, C. Kemner

Clinical Neuropsychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. © 2003 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Journal	Neuroscience Letters
DOIs	https://doi.org/10.1016/j.neulet.2003.09.028
Publication status	Published - 2003

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10.1016/j.neulet.2003.09.028

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title = "Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.",

abstract = "Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. {\textcopyright} 2003 Elsevier Ireland Ltd. All rights reserved.",

author = "M. Lijffijt and \{van Dam\}, P.S. and J.L. Kenemans and H.P.F. Koppeschaar and \{de Vries\}, W.R. and M.L. Drent and A. Wittenberg and C. Kemner",

year = "2003",

doi = "10.1016/j.neulet.2003.09.028",

language = "English",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

AU - Lijffijt, M.

AU - van Dam, P.S.

AU - Kenemans, J.L.

AU - Koppeschaar, H.P.F.

AU - de Vries, W.R.

AU - Drent, M.L.

AU - Wittenberg, A.

AU - Kemner, C.

PY - 2003

Y1 - 2003

N2 - Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. © 2003 Elsevier Ireland Ltd. All rights reserved.

AB - Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. © 2003 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.neulet.2003.09.028

DO - 10.1016/j.neulet.2003.09.028

M3 - Article

SN - 0304-3940

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

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